Preliminary neuropsychological test results

European Journal of Pediatrics
L de SonnevilleU Batzler

Abstract

A series of information processing tasks was administered to 22 PKU children aged 8.5 years who had been under dietary treatment since birth as well as to 20 controls of the same age. This contribution presents the results of two tasks from this series: a continuous performance task and a calculation task. The continuous performance task revealed a sustained attention deficit in the PKU group. In the calculation task the PKU children were slower than the controls and this difference increased with task difficulty. When the PKU sample was divided in two groups (above and below the median value of the concurrent plasma Phe level), the high Phe level group performed much worse in comparison to the low Phe level group. The latter group actually matched performance level of the controls. This could be observed for both tasks. The serum Phe level, assessed since birth over 6 month periods, correlated highly with task performance. As regards sustained attention, the Phe level measured during the 2 years preceeding test administration appeared to be an even better predictor for task performance than the concurrent Phe level, a finding which seems to underline the chronic effect of Phe on basic attention mechanisms. The results so far s...Continue Reading

References

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Citations

Jan 1, 1994·Journal of Inherited Metabolic Disease·S E Waisbren, J Zaff
Jul 1, 1992·European Journal of Pediatrics·J WeglageK Ullrich
Oct 1, 1994·Journal of Clinical and Experimental Neuropsychology·E SchmidtL de Sonneville
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Jan 23, 2003·Developmental Neuropsychology·Stephan HuijbregtsFrancjan van Spronsen
Nov 1, 1994·European Journal of Pediatrics·M M HendrikxA F Kalverboer
Sep 1, 1995·European Journal of Pediatrics·B A StemerdinkP H Verkerk
Mar 23, 2011·Developmental Medicine and Child Neurology·Jaume CampistolUNKNOWN PKU Follow-up Unit
Mar 19, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martine van Dongen-BoomsmaDorine Slaats-Willemse
Oct 31, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Madelon A VollebregtDorine Slaats-Willemse
Dec 30, 2014·Molecular Genetics and Metabolism·Geertje B LiemburgStephan C J Huijbregts
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Mar 21, 2015·Journal of Athletic Training·Michael E Powers
Apr 30, 2019·Journal of the International Neuropsychological Society : JINS·Marie CantonArnaud Roy

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