Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes

Current Medical Research and Opinion
Vincenzo GentileF Di Silverio

Abstract

To investigate the efficacy and tolerability of oral propionyl-L-carnitine (PLC) plus sildenafil in men with erectile dysfunction (ED) and diabetes unresponsive to sildenafil monotherapy. Patients with medically documented ED of organic or mixed aetiology and diabetes (type 1 and 2) were randomised to receive oral PLC (2 g/day) plus sildenafil (50 mg twice weekly) (20 patients, Group 1) or sildenafil alone (20 patients, Group 2), in a double-blind, fixed-dose study. All patients had been previously treated unsuccessfully with a minimum of eight administrations of sildenafil. Efficacy was evaluated using the International Index of Erectile Function (IIEF) questionnaire: total score, subscores for questions 3 (Q3; achieving an erection) and 4 (Q4; maintaining an erection) and global efficacy question (GEQ: 'Has treatment improved your erections?'). Patients Event Logs were also used. After 24 weeks of treatment, mean scores for IIEF Q3 and Q4 had improved significantly in patients of Group 1 (4.25 +/- 0.63 and 3.95 +/- 1.0) compared with Group 2 (2.9 +/- 0.71 and 2.7 +/- 0.96) (p < 0.01). Moreover, the percentage of patients with improved erections (GEQ 68% vs. 23%) and successful intercourse attempts (76% vs. 34%) was significan...Continue Reading

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Citations

Jun 14, 2013·Journal of Translational Medicine·Thomas E IchimAmit N Patel
Mar 23, 2011·Asian Journal of Andrology·Rohit R DhirRun Wang
Apr 28, 2011·Nutrition Reviews·Carmen MingoranceMaria Alvarez de Sotomayor
Jun 5, 2007·Endocrinology and Metabolism Clinics of North America·Ronald Tamler, Jeffrey I Mechanick
Nov 18, 2005·The Urologic Clinics of North America·Puneet MassonRidwan Shabsigh
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Yun ChenRun Wang
Feb 16, 2012·Current Opinion in Gastroenterology·Mariano Malaguarnera
Nov 20, 2009·Neural Computation·Giorgio Gnecco, Marcello Sanguineti
Oct 6, 2018·International Journal of Impotence Research·Taymour MostafaIngi A Mostafa
Apr 23, 2010·Endocrine Research·Fatih KiliçliIlkay Cakir

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