Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy

The British Journal of Ophthalmology
Nadine Gerber-HollbachGerrit R J Melles

Abstract

To evaluate the clinical outcome of a full-diameter, untrephined, semicircular Descemet graft in a consecutive series of Descemet membrane endothelial keratoplasty (hemi-DMEK), potentially allowing the harvesting of two grafts from a single donor corneoscleral rim. Interventional case series of 10 eyes of 10 patients with Fuchs endothelial dystrophy. Best corrected visual acuity (BCVA), endothelial cell density (ECD) and central corneal thickness (CCT) were evaluated up to 6 months postoperatively, and intraoperative and postoperative complications were recorded. Hemi-DMEK was successful in 9 out of 10 eyes; one eye showed persistent graft detachment despite rebubbling and underwent a secondary DMEK. BCVA improved in all successful hemi-DMEK eyes: at 6 months 100% of eyes (n=7) reached ≥20/40 (≥0.5), 86% (n=6) ≥20/25 (≥0.8), 29% (n=2) ≥20/20 (≥1.0) and 14% (n=1) reached 20/17 (≥1.2). Two eyes were excluded from visual analysis due to low visual potential. Preoperative donor ECD declined from 2744 (±181) cells/mm(2) to 940 (±380) cells/mm(2) centrally at 6 months postoperatively (n=9), with (donor and/or host) endothelial cell redistribution over bare stromal areas adjacent to the graft. Average CCT decreased from 745 (±153) µm ...Continue Reading

References

Apr 11, 2007·Archives of Ophthalmology·Rasik B VajpayeeRadhika Tandon
Aug 30, 2008·Journal of Cataract and Refractive Surgery·Jessica T LieGerrit R J Melles
Jan 12, 2011·Archives of Ophthalmology·Isabel DapenaGerrit R J Melles
Jan 4, 2012·British Journal of Anaesthesia·L GaumS B Kaye
Sep 12, 2012·JAMA Ophthalmology·Vasilios S LiarakosGerrit R J Melles
Sep 22, 2012·American Journal of Ophthalmology·Lamis BaydounGerrit R J Melles
Jan 9, 2013·Current Eye Research·Ruth QuilendrinoGerrit R J Melles
Jul 6, 2014·JAMA Ophthalmology·Claire MonnereauGerrit R J Melles
Dec 3, 2014·Ophthalmology·Marina Rodríguez-Calvo-de-MoraGerrit R J Melles
Oct 29, 2015·The British Journal of Ophthalmology·Jessica T LieGerrit R J Melles

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Citations

Mar 1, 2018·Cornea·Oganes G OganesyanVostan R Getadaryan
Mar 3, 2018·Acta Ophthalmologica·Lamis BaydounGerrit R J Melles
May 3, 2019·Current Opinion in Ophthalmology·Joao V Godinho, Shahzad I Mian
May 22, 2020·Progress in Retinal and Eye Research·Stephan Ong ToneUla V Jurkunas
Sep 19, 2020·Cornea·Kunal A GadhviVito Romano

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