Feb 1, 1980

Preliminary pharmacological characterization of the bovine isolated bronchial artery strip: a new preparation

British Journal of Pharmacology
R O Arowolo, P Eyre

Abstract

1 This paper describes a preliminary pharmacological study of the isolated helical strip of bovine bronchial artery under isotonic conditions in Krebs-Henseleit solution. 2 The tissue contracted to histamine and 5-hydroxytryptamine (5-HT), actions which were selectively antagonized by mepyramine and methysergide respectively. Histamine was not inhibited by metiamide and 5-HT was not affected by morphine. 3 Slow reacting substance of anaphylaxis (SRS-A), prostaglandin F2 alpha (PGF2 alpha) and PGE2 were spasmogenic, whereas PGE1 caused relaxation. No potential antagonists of these agents were tested. 4 Carbachol, at all concentrations, caused contractions of the bronchial artery which were completely, irreversibly blocked by atropine. 5 The spasmogenic action of phenylephrine was selectively blocked by dibenamine. Vessel strips which were partially contracted to histamine, relaxed to isoprenaline and salbutamol. The action of isoprenaline was inhibited similarly by either propranolol or practolol. The evidence therefore suggests the presence of functional alpha, beta 1 and beta 2-adrenoceptors.

  • References8
  • Citations6

References

Mentioned in this Paper

Muscle, Smooth, Vascular
Histamine Measurement
Entire Bronchial Artery
Pyrilamine
Prostaglandin F2 Alpha Measurement
Practolol
Morphine Measurement
Serotonin
Bos taurus
Atropine

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