Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women.

Biopharmaceutics & Drug Disposition
Ling SongTianyan Zhou

Abstract

The aim of this study was to build and verify a preliminary physiologically based pharmacokinetic (PBPK) model of Chinese pregnant women. The model was used to predict maternal pharmacokinetics (PK) of 6 predominantly renally cleared drugs. Based on SimCYP Caucasian pregnancy population dataset, the preliminary Chinese pregnant population was built by updating several key parameters and equations according to physiological parameters of Chinese (or Japanese) pregnant women. Drug-specific parameters of 6 renally cleared drugs were validated through PBPK modeling of Caucasian non-pregnant, Caucasian pregnant and Chinese non-pregnant population. The preliminary PBPK model of Chinese pregnant population was then developed by integrating the preliminary Chinese pregnant population and the drug-specific parameters. This model was verified by comparing the predicted maternal PK of these 6 drugs with the observed in vivo data from the literature. The preliminary Chinese pregnant population PBPK model successfully predicted the PK of 6 target drugs for different pregnancy stages. The predicted plasma concentrations time profiles fitted the observed data well, and most predicted PK parameters were within 2-fold of observed data. The prel...Continue Reading

References

Nov 14, 1977·European Journal of Clinical Pharmacology·P E Gower, C H Dash
May 1, 1976·Antimicrobial Agents and Chemotherapy·R D Foord
Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Nilsson-EhleS R Norrby
Oct 1, 1989·Clinical Pharmacokinetics·J H YukR Quintiliani
Jun 1, 1989·Journal of Chemotherapy·M A el GuinaidyM S Sabbour
Dec 1, 1986·The Journal of Antimicrobial Chemotherapy·R WiseJ M Andrews
Jan 1, 1988·European Journal of Clinical Pharmacology·B Ljungberg, I Nilsson-Ehle
Sep 1, 1983·Antimicrobial Agents and Chemotherapy·E A SwabbA Sugerman
Apr 1, 1982·American Journal of Obstetrics and Gynecology·A Philipson, G Stiernstedt
Feb 1, 1981·British Journal of Obstetrics and Gynaecology·P BousfieldM Elstein
Feb 1, 1994·British Journal of Clinical Pharmacology·C A VerhagenE Van Strijen
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·W PaulfeuerbornH Lode
May 1, 1993·Journal of Clinical Pharmacology·B R MeyersS Z Hirschman
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·P BourgetC Delouis
Jan 1, 1993·Chemotherapy·S RipaM Prenna
Jan 1, 1993·Clinical Pharmacokinetics·D Debruyne, J P Ryckelynck
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T J PursleyJ A Bartley
Jun 15, 1999·Journal of the American Academy of Dermatology·J Faergemann
May 26, 2006·Journal of Medicinal Chemistry·Natalia DíazM Angeles Jiménez
Mar 3, 2007·Clinical Pharmacology and Therapeutics·M A AndrewM F Hebert
Feb 2, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sara EyalMary F Hebert
Mar 25, 2015·Journal of Diabetes·Mladena Lalic-PopovicMomir Mikov
Oct 22, 2015·Obstetrics and Gynecology·UNKNOWN Committee on Ethics
Jan 16, 2016·Journal of Midwifery & Women's Health·Susan M SinclairElizabeth M Cooper
Apr 16, 2016·Clinical Pharmacology and Therapeutics·Yasar TasnifMary F Hebert
Jun 24, 2016·The Journal of Antimicrobial Chemotherapy·Christopher Ramsey, Alasdair P MacGowan
Apr 10, 2017·Clinical Pharmacokinetics·André DallmannGeorg Hempel
Sep 20, 2017·British Journal of Clinical Pharmacology·Sílvia M IllamolaAnne Zajicek
Apr 10, 2018·Obstetrics and Gynecology·David M HaasUma M Reddy
Apr 11, 2018·Clinical Pharmacology and Therapeutics·André DallmannThomas Eissing
Jul 31, 2018·Open Heart·Takeshi UmazumeHisanori Minakami
Aug 17, 2018·Journal of Clinical Pharmacology·André DallmannGilbert Koch

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