Preliminary report: functional MRI of the brain may be the ideal tool for evaluating neuropsychologic and sleep complaints of patients with primary hyperparathyroidism

World Journal of Surgery
Nancy D PerrierPaul J Laurienti

Abstract

The incidence, pattern, and severity of sleep disturbance and cognitive dysfunction has not been well characterized for patients with primary hyperparathyroidism (PHPT). There is no agreement on the mechanism of the development or resolution of such symptoms, and in no previous study has cerebral activity been functionally assessed and change documented following surgical cure of patients with PHPT. We undertook a prospective analysis to obtain pilot data on 6 patients with PHPT. Functional magnetic resonance imaging (fMRI), formal neuropsychologic (NP) tests, and health-related quality of life (HRQL) measures that included sleep assessments were performed on patients before and after parathyroidectomy. Changes in cortical activation under both conflict and neutral conditions (distracting tasks) were recorded. Functional MRI demonstrated postoperative changes in medial prefrontal cortex activity during cognitive processing of conflict and nonconflict tasks. Further postoperative changes were noted in the dorsolateral prefrontal cortex and parietal cortex with shifts in activations. In addition to the fMRI findings, the patients demonstrated improvements in sleep and social behavior. They tended to experience less fatigue and th...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J V PardoM E Raichle
Apr 1, 1988·The Nebraska Medical Journal·J Stavas
Nov 1, 1983·Australian Journal of Ophthalmology·T P WerblinR Peiffer
May 1, 1995·The Annals of Thoracic Surgery·D A Stump
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
May 23, 1998·World Journal of Surgery·H ChenR Udelsman
Jun 5, 1999·Reviews in the Neurosciences·C S CarterJ D Cohen
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·S J SilverbergA F Stewart
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S KhoslaB l Riggs
Oct 21, 1999·The New England Journal of Medicine·S J SilverbergJ P Bilezikian
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Sep 9, 2000·Brain Research. Cognitive Brain Research·M T BanichC Brown
Nov 18, 2000·American Journal of Ophthalmology·J DuncanH Emslie
Dec 16, 2000·The New England Journal of Medicine·S J Marx
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S P Drummond, G G Brown
Sep 7, 2002·Archives of Surgery·David G SheldonJohn A Ryan
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Mar 1, 1962·The Journal of Genetic Psychology·P E COMALLIH WERNER
Dec 4, 2003·Medical Image Analysis·Klaus A GanserChristian R Wirtz
Apr 26, 2005·Aging Clinical and Experimental Research·Camilla PreteErnesto Palummeri
Oct 26, 2005·Annals of Surgery·Laura H CokerNancy Perrier
Jan 1, 1994·Human Brain Mapping·K J FristonA C Evans

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Citations

Oct 8, 2009·Journal of the International Neuropsychological Society : JINS·Jared F BengeJeffrey S Wefel
Nov 30, 2006·Current Opinion in Oncology·Sanziana Roman, Julie Ann Sosa
Mar 17, 2009·World Journal of Surgery·Nadine R Caron, Janice L Pasieka
Jul 29, 2008·Clinical Neurology and Neurosurgery·Sokratis G PapageorgiouNikolaos Kalfakis
May 27, 2015·PloS One·Ilianna LouridaDavid J Llewellyn
Sep 22, 2018·CA: a Cancer Journal for Clinicians·Jonathan ZagzagNancy D Perrier
May 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Marcella D Walker, Shonni J Silverberg
Feb 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Robert UdelsmanOrlo H Clark
Feb 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Shonni J SilverbergMishaela R Rubin
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Scott N Pinchot, Herbert Chen
Nov 30, 2006·Current Opinion in Oncology

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