PMID: 6106204Aug 1, 1980Paper

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

Pharmacology, Biochemistry, and Behavior
J Crawley, F K Goodwin

Abstract

A simple system is described to analyze the possibility that increased exploratory behavior is an index for the anxiolytic effects of benzodiazepines in laboratory rodents. Mice were allowed free run in a two-chambered arena, where two-thirds of the area was illuminated and one-third was darkened. The two chambers were separated by a black partition equipped with photocells across the opening, and the entire cage rested on an Animex activity monitor. Transitions across the partition between the light and dark chambers, and total Animex locomotor activity, were increased by clonazepam and chlordiazepoxide, in dose-dependent ranges consistent with previously reported behavior models. The increased exploratory activity with benzodiazepines does not appear to be a non-specific increase in general motor activity, as locomotion in clonazepam and chlordiazepoxide treated mice placed in a bare, undifferentiated cage was not significantly different from vehicle treated mice.

References

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Citations

Jan 1, 1990·Psychopharmacology·A Fernández-Guasti, C López-Rubalcava
Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Aug 7, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·I P AnokhinaO B Petrichenko
Feb 5, 2013·Journal of Natural Medicines·Machiko TanakaKazuo Koike
Jan 15, 1988·Biological Psychiatry·R S KahnG Barr
Nov 29, 1986·Brain Research·J N CrawleyS M Paul
Feb 19, 1981·European Journal of Pharmacology·P SkolinickJ Cook
Jan 27, 1984·European Journal of Pharmacology·J N CrawleyF Baldino
Mar 12, 1985·European Journal of Pharmacology·H RommelspacherR Hill
Dec 16, 1986·European Journal of Pharmacology·C B Smith, J N Crawley
Dec 21, 1993·European Journal of Pharmacology·S C StrattonM B Tyers
Jul 6, 1993·European Journal of Pharmacology·J D BrioniM W Decker
Apr 1, 1994·European Journal of Pharmacology·C H ChengR J Naylor
Dec 27, 1995·European Journal of Pharmacology·T J ZethofB Olivier
Dec 1, 1983·Neuropharmacology·H Lal, M W Emmett-Oglesby
Feb 1, 1987·Neuropharmacology·B CostallR J Naylor
Sep 1, 1981·Physiology & Behavior·J N CrawleyF K Goodwin
Jan 1, 1994·Physiology & Behavior·T J ZethofB Olivier
Oct 1, 1981·Pharmacology, Biochemistry, and Behavior·D R Britton, K T Britton
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·L K Blumstein, J N Crawley

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