PMID: 11314943Apr 21, 2001Paper

Preliminary report of photodynamic therapy for intraperitoneal sarcomatosis

Annals of Surgical Oncology
T W BauerD L Fraker

Abstract

Sarcomatosis is the disseminated intraperitoneal spread of sarcoma. It is a condition for which there is no effective treatment. Photodynamic therapy (PDT) is a cancer treatment modality that uses a photosensitizing agent and laser light to kill cells. We report our preliminary Phase II clinical trial experience using PDT for the treatment of intraperitoneal sarcomatosis. From May 1997 to December 1998 eleven patients received twelve PDT treatments for intraperitoneal sarcomatosis. Photofrin (PF) 2.5 mg/kg was administered intravenously 48 hours before surgical debulking to a maximum residual tumor size of less than 5 mm. Light therapy was administered at a fluence of 2.5 J/cm2 of 532 nm green light to the mesentery and serosa of the small bowel and colon; 5 J/cm2 of 630 nm red light to the stomach and duodenum; 7.5 J/cm2 of red light to the surface of the liver, spleen, and diaphragms; and 10 J/cm2 of red light to the retroperitoneal gutters and pelvis. Light fluence was measured with an on-line light dosimetry system. Response to treatment was evaluated by abdominal CT scan at 3 and 6 months, diagnostic laparoscopy at 3 to 6 months, and clinical examination every 3 months. Adequate tumor debulking required an omentectomy in e...Continue Reading

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Citations

Jul 26, 2008·Journal of Photochemistry and Photobiology. B, Biology·D Gayathri DeviAnnie Abraham
Nov 19, 2011·Journal of Clinical Periodontology·Valdir Gouveia GarciaLetícia Helena Theodoro
Aug 4, 2004·The Lancet Oncology·Stanley B BrownIan Walker
May 3, 2006·The Journal of Surgical Research·H M RossS M Hahn
Mar 29, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stanley S Stylli, Andrew H Kaye
Dec 13, 2005·Cancer Treatment Reviews·Simone MocellinDonato Nitti
Nov 29, 2001·Photochemistry and Photobiology·R AckroydM Reed
Oct 20, 2005·Journal of the National Cancer Institute·Marcela G del CarmenTayyaba Hasan
Feb 18, 2020·Photodiagnosis and Photodynamic Therapy·Henri AzaïsSerge Mordon
Apr 5, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·H AzaïsP Collinet

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