Preliminary Report on the Association Between STAT3 Polymorphisms and Susceptibility to Acute Kidney Injury After Cardiopulmonary Bypass

Biochemical Genetics
Sara Aghakhani ChegeniNadereh Naderi

Abstract

Cardiopulmonary bypass-associated acute kidney injury (CPB-AKI) is a well-recognized complication which is clearly linked to increased morbidity and mortality. Due to important role of inflammation in CPB-AKI pathogenesis, we explored the association between polymorphisms in STAT3, an inflammation-associated transcription factor, and the risk of CPB-AKI. In this study, STAT3 rs1053004 and rs744166 polymorphisms were analyzed in 129 patients undergoing coronary artery bypass grafting in Jorjani heart center, Bandar Abbas, Iran. The genotypes were determined using sequence-specific primers (PCR-SSP). Sixty-three patients met the criteria for AKI after cardiac surgery (AKI group). The remaining 66 patients did not develop AKI (non-AKI group). Rs1053004 GG genotype was significantly associated with a decreased risk (OR 0.4, 95% CI 0.17-0.9, P = 0.03) of CPB-AKI. Subgroup analyses revealed that GG genotype has also a protective effect in older patients (Age ≥ 60) (OR 0.19, 95% CI 0.04-0.8, P = 0.01). However, rs744166 did not show any difference between AKI and non-AKI groups. The result of our study for the first time provides evidence that rs1053004 polymorphism is significantly associated with a decreased risk of CPB-AKI in Irani...Continue Reading

References

May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Sep 23, 2003·Immunity·Fengdong ChengEduardo M Sotomayor
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Mario GaudinoGianfederico Possati
Jul 28, 2004·The Annals of Thoracic Surgery·G Burkhard MacKensenUNKNOWN Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center
Oct 4, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David R HodgeWilliam L Farrar
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mitchell H Rosner, Mark D Okusa
Oct 9, 2007·The Heart Surgery Forum·Selim C IsbirSinan Arsan
Jan 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph F DastaJohn A Kellum
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Feb 26, 2010·Mediators of Inflammation·Ali AkcayCharles L Edelstein
Sep 3, 2010·Human Mutation·Maxim BarenboimDaniel R Weinberger
Dec 29, 2010·Cell Research·Guobin He, Michael Karin
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·A Richard Kitching, Stephen R Holdsworth
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Annalisa Camporeale, Valeria Poli
Sep 10, 2013·Best Practice & Research. Clinical Anaesthesiology·Matthias HeringlakeHauke Paarmann
Jul 1, 2012·JAK-STAT·Arash HaghikiaDenise Hilfiker-Kleiner
Nov 7, 2013·Physiological Genomics·Qing CaoTing-Ting Huang
Nov 16, 2013·Current Opinion in Nephrology and Hypertension·Gilbert R Kinsey, Mark D Okusa
Jan 24, 2014·Cardiorenal Medicine·Huijuan MaoClaudio Ronco
Apr 17, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jason H GreenbergUNKNOWN TRIBE-AKI Consortium
Dec 1, 2013·Drug Discovery Today. Disease Mechanisms·Thomas Weimbs, Jeffrey J Talbot
Jul 5, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jason B O'NealFrederic T Billings
Jul 7, 2017·American Journal of Physiology. Renal Physiology·Ravindra BodduLisa M Curtis
Nov 29, 2017·Journal of Immunology Research·Shataakshi DubeTimothy A Sutton
Dec 12, 2017·Clinical Kidney Journal·Benjamin A VervaetAnja Verhulst

❮ Previous
Next ❯

Citations

Jun 20, 2019·American Journal of Physiology. Renal Physiology·Karl A NathGregory M Vercellotti
Jul 25, 2021·Journal of Clinical Medicine·Christian Ortega-LoubonEduardo Tamayo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Primer3 Primer Blast
Statistical Package for Social Sciences

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.