Preliminary results of identification and quantification of paclitaxel and its metabolites in human meconium from newborns with gestational chemotherapeutic exposure

PloS One
Elyce CardonickNathaniel W Snyder

Abstract

Cancer diagnosis during pregnancy occurs in 1 out of 1000 pregnancies with common malignancies including breast and hematological cancers. Fetal exposure to currently utilized agents is poorly described. We directly assessed fetal exposure by screening meconium from 23 newborns whose mothers had undergone treatment for cancer during pregnancy. Meconium was collected from newborns whose mothers were diagnosed with cancer during pregnancy and underwent chemotherapy in the second or third trimester as part of the Cancer and Pregnancy Registry. We conducted screening of 23 meconium samples for chemotherapeutics and known metabolites of chemotherapeutics by liquid chromatography-high resolution mass spectrometry (LC-HRMS). Putative identification of paclitaxel and/or its metabolites was made in 8 screened samples. In positively screened samples, we quantified paclitaxel, 3'-p-hydroxypaclitaxel, and 6α-hydroxypaclitaxel by stable isotope dilution-LC-HRMS. Mean (standard deviation) levels of paclitaxel in positively screened samples were 399.9 (248.6) pg/mg in meconium samples from newborn born to mothers that underwent chemotherapy during pregnancy. 3'-p-hydroxypaclitaxel and 6α-hydroxypaclitaxel mean levels were 105.2 (54.6) and 113...Continue Reading

References

Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L BerryG N Hortobagyi
Nov 24, 1999·The Journal of Clinical Investigation·J W SmitA H Schinkel
Feb 7, 2002·European Journal of Cancer Care·M De SantisA Caruso
Jan 30, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael S AlexanderSteve J Bannister
Nov 11, 2003·Obstetrics and Gynecology·Luis E MéndezVíctor Hugo González-Quintero
May 4, 2004·The Lancet Oncology·Elyce Cardonick, Audrey Iacobucci
Oct 16, 2004·Expert Review of Anticancer Therapy·Boaz WeiszMichael Lishner
Mar 10, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·M C Gainford, M Clemons
Apr 6, 2006·Clinical Breast Cancer·Yago NietoGuillermo López
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Feb 27, 2009·Archives of Gynecology and Obstetrics·Abdulrahim A RouziMahmoud S Alahwal
Nov 3, 2009·Journal of Fish Diseases·N G H TaylorK Way
Nov 6, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O MirR Rouzier
Nov 10, 2009·Biochemical Pharmacology·Sarah J HemauerMahmoud S Ahmed
Feb 19, 2010·The Cancer Journal·Elyce CardonickAniqa Usmani
Nov 9, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Martin N FranssonLena E Friberg
Aug 10, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E CardonickR Somer
Nov 24, 2012·American Journal of Obstetrics and Gynecology·Paul BerveillerJean-Marc Tréluyer
May 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne-Joy M de GraanRon H N van Schaik
Dec 3, 2014·Annals of Epidemiology·Bo Y Park, Brian K Lee
Sep 29, 2015·The New England Journal of Medicine·Frédéric AmantUNKNOWN International Network on Cancer, Infertility, and Pregnancy (INCIP)
Nov 23, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Alexander J FreyNathaniel W Snyder
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E CardonickR Somer

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Citations

Feb 7, 2020·Current Oncology Reports·Charlotte MaggenUNKNOWN International Network on Cancer, Infertility and Pregnancy (INCIP)
Sep 22, 2020·Advanced Drug Delivery Reviews·Christian G Figueroa-EspadaRachel S Riley

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