PMID: 7515643Jan 1, 1994Paper

Preliminary results of the EORTC-GPMC controlled clinical trial H7 in early-stage Hodgkin's disease. EORTC Lymphoma Cooperative Group. Groupe Pierre-et-Marie-Curie

Annals of Oncology : Official Journal of the European Society for Medical Oncology
E M NoordijkNoëlle Dupouy

Abstract

In this phase III trial, 770 patients with clinical stage I-II Hodgkin's disease (HD) have been enrolled since November 1988. Preliminary results are given for the 605 (79%) patients who have completed their initial therapy. Patients were grouped according to 6 pretreatment prognostic characteristics. In the very favourable (VF) group, treatment consisted of mantle field alone. In the favourable (F) group, patients were randomized to either subtotal nodal irradiation (STNI), or 6 cycles of EBVP (epirubicin, bleomycin, vinblastine, prednisone) followed by involved-field irradiation (IF-RT). Unfavourable (U) patients were randomized to either 6 cycles of EBVP plus IF-RT, or to 6 cycles of MOPP/ABV hybrid plus IF-RT. Of the 35 VF patients, none have progressed during radiotherapy. Four patients relapsed and were salvaged. Three-year failure-free survival (FFS) was 82%; overall survival (OS) was 100%. Of the 254 F patients, 130 were treated with STNI and 124 with EBVP plus IF-RT. At 3 years, FFS rates were 81% (1 progression, 14 relapses) and 79% (5 progressions, 8 relapses), respectively. Corresponding OS rates were 99% and 100%. Of the 316 U patients, 160 received EBVP and 156 MOPP/ABV. At 3 years, FFS rates were 72% (18 progress...Continue Reading

Citations

Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A K NgK M Kuntz
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E DühmkeV Diehl
Aug 9, 2006·Current Opinion in Oncology·David J Straus
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Belinda A CampbellJoseph M Connors
Jun 15, 2011·Journal of Internal Medicine·D J Straus
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Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O W PressR I Fisher
Jul 13, 2005·European Journal of Haematology. Supplementum·Houchingue EghbaliUNKNOWN EORTC Lymphoma Group
Apr 6, 2011·Leukemia & Lymphoma·Lauren S MaedaRanjana H Advani
Nov 28, 2001·Hematology·J M ConnorsS J Horning
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Berthe M P AlemanFlora E van Leeuwen
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Apr 18, 1998·Medizinische Klinik·H TeschA Engert
Nov 15, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D de JongUNKNOWN Groupe d'Etude des Lymphomes de l'Adulte

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