PMID: 6107103Jan 1, 1980Paper

Preliminary review of the interactions of ORG NC 45 with anaesthetics and antibiotics in animals

British Journal of Anaesthesia
N KriegL H Booij

Abstract

In vitro (rat hemidiaphragm) and in vivo (rat and cat tibialis anterior muscle preparation) studies of the interactions between Org NC 45 and some i.v. anaesthetics and antibiotics were carried out. With the exception of ketamine 1 mg kg-1 none of the drugs tested in vivo significantly changed the time course of an Org NC 45 bolus injection. All of the drugs caused an enhancement of the neuromuscular block using infusions in vivo and also in the in vitro preparations. Org NC 45 seems to be potentiated in a manner similar to pancuronium.

Citations

Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T M HemmerlingH Schwilden
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·K S Khuenl-BradyR D Miller
Feb 19, 1982·Pharmaceutisch Weekblad. Scientific Edition·L H BooijJ E Crul

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