PMID: 8597653Nov 1, 1995Paper

Preliminary screening for the potential of drinking water disinfection byproducts to alter male reproduction

Reproductive Toxicology
G R KlinefelterAnthony B DeAngelo

Abstract

There is increasing epidemiologic interest in the role drinking water disinfection byproducts (DBPs) may play in adverse reproductive outcomes such as inability to conceive, spontaneous abortion, and low birth weight. Although dozens of DBPs already have been identified, only a few studies have attempted to determine whether DBPs alter male reproductive parameters such as testicular and epididymal histology, testicular and epididymal sperm numbers, and epididymal sperm morphology and motility in laboratory animals. In these studies, alterations in epididymal sperm motility seemed to be predictive of more generalized toxicity of the male reproductive system. Because there is a need to prioritize DBPs for thorough reproductive and developmental toxicity testing, preliminary screening for the potential of DBPs to alter reproductive function seems warranted. Here, we elected to examine only cauda epididymal sperm motion parameters and testicular and epididymal histopathology. The effects of exposure to two commonly occurring DBPs, bromodichloromethane (BDCM) and chloral hydrate (CH), via drinking water were evaluated in F344 rats at an interim (52 week) necropsy during cancer bioassay studies. Exposure to 22 and 39 mg/kg BDCM and 5...Continue Reading

References

Jan 1, 1992·Reproductive Toxicology·G P TothM K Smith
Jul 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G P TothM K Smith
Dec 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W F BlazakB E Stewart
May 1, 1994·Reproductive Toxicology·R E LinderC J Dyer
Oct 1, 1983·Environmental Science & Technology·R F ChristmanA A Stevens

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Citations

Apr 10, 2002·Journal of Toxicology and Environmental Health. Part a·Benoît LévesqueEric Dewailly
Jan 23, 2004·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Mar 11, 2000·Occupational and Environmental Medicine·M J NieuwenhuijsenP Elliott
Jun 14, 2013·Occupational and Environmental Medicine·Nina IszattMireille B Toledano
Oct 22, 2013·Occupational and Environmental Medicine·Sylvaine Cordier
Apr 4, 2014·Environmental Health Perspectives·Qiang ZengWen-Qing Lu
Mar 9, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S R BielmeierM G Narotsky
Aug 2, 2015·Current Environmental Health Reports·Cristina M VillanuevaPatrick Levallois
Oct 22, 2003·Epidemiology·Laura FensterShanna H Swan
May 23, 2002·International Journal of Toxicology·M S ChristianW Ray Brown
Sep 5, 2002·Journal of Applied Toxicology : JAT·R PoonV E Valli
Feb 17, 2001·Journal of Applied Toxicology : JAT·R PoonI Chu

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