PMID: 7284435Jul 28, 1981Paper

Preliminary spectroscopic characterization of six toxins from Latin American scorpions

Biochimica Et Biophysica Acta
L D PossaniK Wüthrich

Abstract

This paper reports on spectroscopic studies of six toxins from the Latin American scorpions Centruroides noxius Hoffmann, Centruroides elegans Thorell and Tityus serrulatus Lutz and Mello. The isolation and purification of five of these toxins was described previously. The preparation of toxin II.9.2.2 from the venom of C. noxius is first described here. Circular dichroism and nuclear magnetic resonance spectra indicate similarities and differences between these scorpion toxins and previously characterized snake toxins. While there is evidence that the toxins from scorpions and snakes both contain extended beta-sheet secondary structures, the spectral properties of the scorpion toxins are overall of a different type from those of snake toxins. Among the six scorpion toxins those from T. serrulatus have spectral properties markedly different from those of the Centruroides species. Furthermore, thermal denaturation and amide proton exchange measurements showed that the globular structures of the Tityus toxins were markedly less stable and less rigid than those of the Centruroides toxins.

References

May 5, 1979·Journal of Molecular Biology·K Wüthrich, G Wagner
May 5, 1979·Journal of Molecular Biology·R RicharzK Wüthrich
Jun 1, 1976·Biochemistry·C Habersetzer-Rochat, F Sampieri
Apr 30, 1977·Archives of Biochemistry and Biophysics·L D PossaniB W Erickson
Jun 20, 1977·Biochemical and Biophysical Research Communications·J LauterweinM Lazdunski
Jul 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R Rüchel
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B W LowJ S Richardson
Jan 1, 1975·Archives of Biochemistry and Biophysics·D R BabinR V Mlejnek
Jul 24, 1972·European Journal of Biochemistry·H RochatS Lissitzky
Oct 1, 1974·Archives of Biochemistry and Biophysics·D R BabinR V Mlejnek
Jan 1, 1972·Annual Review of Biochemistry·S W EnglanderH Teitelbaum
Jan 1, 1966·Advances in Protein Chemistry·A Hvidt, S O Nielsen
Jul 1, 1970·European Journal of Biochemistry·R Chicheportiche, M Lazdunski
Dec 1, 1970·European Journal of Biochemistry·H RochatP Edman
Jul 15, 1971·European Journal of Biochemistry·E KarlssonD Eaker
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·M A DentP L Fletcher

Citations

Mar 16, 2006·Parasitology Research·Adolfo BorgesOlinda Delgado
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A B AlagónL D Possani
Aug 19, 2007·The Journal of General Physiology·Fabiana V CamposFrancisco Bezanilla
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·N R KrishnaD D Watt
Sep 24, 1987·Biochimica Et Biophysica Acta·E P ArêasY Kawano

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