Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Rakesh Sharma, Jose Katz

Abstract

Aldosterone has direct or indirect effects on atherosclerosis, and polymorphisms occur in the gene encoding aldosterone synthase (CYP11B2), the enzyme catalysing aldosterone biosynthesis. Genetic variations in aldosterone synthesis may influence progression of carotid atherosclerosis. Ten subjects were genotyped through the use of the polymerase chain reaction for two diallelic polymorphisms in CYP11B2: one in the transcriptional regulatory region (promotor) and the other in the second intron. In vivo plaque size was estimated by H-1 magnetic resonance imaging using gradient echo pulse sequence. Media-intima thickness and ex vivo plaque in endarterectomy samples were measured by histology. Matrix metalloprotease (MMP)-9 was stained in endarterectomy histology sections and apoptosis index was counted in these sections. The CYP11B2 promoter genotype patterns were associated significantly with the plaque size in carotid artery (r(2)=0.9987; p=0.001), MMP-9 levels (r( 2)=0.9878; p=0.0001) and apoptotic indices (r(2)=0.9495; p=0.005) by multiple regression analysis. The media-intima thickness was not significantly correlated with genotype patterns. Genetic variations in aldosterone synthase (CYP11B2) gene are associated with the pro...Continue Reading

References

Mar 30, 1994·Biochemical and Biophysical Research Communications·S OdakeY Nagai
Jan 1, 1993·American Journal of Hypertension·G RossiA C Pessina
Aug 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J HungJ P Beilby
Feb 22, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·X H HuangT Lehtimäki
Jan 14, 2003·Annals of Medicine·Manuel RodríguezJutta Schaper
Mar 21, 2003·Cerebrovascular Diseases·Dénes PállUNKNOWN Debrecen Hypertension Study
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Jérôme NicodPaolo Ferrari
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Fakhredin A Sayed-TabatabaeiJacqueline C M Witteman
May 12, 2004·Atherosclerosis·Francesco U S Mattace-RasoJacqueline C M Witteman
Apr 6, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Małgorzata Bednarska-MakarukHanna Wehr
Aug 6, 2005·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Rakesh Sharma
Aug 5, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Salman ChoudharyJoel D Morrisett

❮ Previous
Next ❯

Citations

Jun 22, 2012·The Canadian Journal of Cardiology·Omar de RitaJ David Spence
Jul 28, 2011·NMR in Biomedicine·Uma SharmaNaranamangalam R Jagannathan
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rani G SahNaranamangalam R Jagannathan
Nov 12, 2017·Journal of Clinical Pathology·Vishal S ChandanTsung-Teh Wu
May 23, 2020·Current Atherosclerosis Reports·Minghua Liu, Jose Gutierrez
Apr 3, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bo YangTian-De Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.