Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization

Heliyon
Muhammad IqbalMuhamad Sahlan

Abstract

Several studies have previously reported propolis, or its constituents, to inhibit tumour angiogenesis. The anti-angiogenic activity of two Indonesian stingless bee propolis extracts from Sulawesi Island on vascular cells were assessed. Sample D01 was obtained from the outer side of bee hives, while D02 was from the inner side of the same hives. The extracts were profiled by using liquid chromatography coupled to high resolution mass spectrometry. The anti-angiogenic capacity was assessed on HUVECs and placenta-derived pericytes by cell viability, multi-channel wound healing, and CoCl2 based-hypoxia assays. The exact chemical composition has not been confirmed. The most abundant compounds in Indonesian sample D01 seem to be unusual since they do not immediately fall into a clear class. Two of the most abundant compounds have elemental compositions matching actinopyrones. Identification on the basis of elemental composition is not definitive but compounds in D01 are possibly due to unusually modified terpenoids. Sample D02 has abundant compounds which include four related diterpenes with differing degrees of oxygenation and some sesquiterpenes. However, again the profile is unusual. The anti-angiogenic assays demonstrated that D...Continue Reading

Citations

Jun 24, 2020·Biomolecules·Mohammad A I Al-HatamlehMohd Zulkifli Mustafa
Mar 12, 2020·International Journal of Molecular Sciences·Yahima Frión-HerreraMaria Carrara
Jul 2, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Annisa FitriaYandi Syukri
Aug 28, 2021·Nutrients·Ewa Forma, Magdalena Bryś

❮ Previous
Next ❯

Software Mentioned

Excel
ImageJ
OPLSDA
Simca P
Graphpad Prism

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Veterinariia
Z G Chanyshev, A K Kudashev
Asian Pacific Journal of Tropical Biomedicine
Paula M KustiawanChanpen Chanchao
International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
J J BoelensP Lever
Memórias do Instituto Oswaldo Cruz
Gérzia Maria de Carvalho MachadoSolange Lisboa De Castro
Zhong yao tong bao = Bulletin of Chinese materia medica
B J Wang, H J Zhang
© 2021 Meta ULC. All rights reserved