Preliminary study of epidural nalbuphine in treatment of post operative pain: a comparison with equipotent dose of epidural morphine

Journal of Anesthesia
N Weksler, L Ovadia

Abstract

Epidural analgesia was used in 45 patients submitted to upper abdominal surgery. In 30 of them 0.15 mg/kg nalbuphine (EN group) was injected and in the remained, an equipotent dose of 0.1 mg/kg of preservative free morphine (EM group) was used. The patients were observed concerning the severity of pain before and after narcotic administration, duration of analgesia, occurrence and severity of side effects among them. The severity of pain was stated by the McGill pain score (from 0 to 5). Duration of analgesia was defined as the time interval from pain relief after narcotic administration until requirement of an additional epidural narcotic injection. The adequacy of ventilation was estimated by sequential measurements of arterial PCO2. Pain relief was excellent in all patients after both narcotics administration. The analgesia time was significantly longer with epidural morphine than in the EN patients. Besides drowsiness, the other side effects incidence was lower with epidural nalbuphine than with epidural morphine. Two patients in the EM group presented clinical respiratory depression, showing a significant increase in arterial PCO2. We believe that the lack of respiratory depression seen in EN group is a consequence of the ...Continue Reading

References

Mar 10, 1979·Lancet·M BeharJ T Davidson
Jun 1, 1986·British Journal of Anaesthesia·I D KlepperW W Mapleson
Sep 1, 1974·American Journal of Surgery·J AliH B Hechtman
Nov 1, 1981·Canadian Anaesthetists' Society Journal·R L KnillW R Thompson
Mar 1, 1983·Anesthesiology·P R BromageC H Nielsen
Jun 1, 1982·Anesthesiology·P R BromageC H Nielsen
Apr 1, 1980·Clinical Pharmacology and Therapeutics·A Romagnoli, A S Keats

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Citations

Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W R CamannS Datta
Apr 23, 2016·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore
May 2, 2013·The Cochrane Database of Systematic Reviews·Jinlin YangYiping Wang

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