Preliminary Study of MR Diffusion Tensor Imaging of the Liver for the Diagnosis of Hepatocellular Carcinoma

PloS One
Xinghui LiJiani Hu

Abstract

To evaluate the feasibility of differentiating between hepatocellular carcinomas (HCC) and healthy liver using diffusion tensor imaging (DTI). All subjects underwent an abdominal examination on a 3.0T MRI scanner. Two radiologists independently scored the image quality (IQ). An optimal set of DTI parameters was obtained from a group of fifteen volunteers with multiple b-values (100, 300, 500, and 800 s/mm2) and various diffusion-encoding directions (NED = 6, 9, and 12)using two way ANOVA analysis. Eighteen Patients with HCC underwent DTI scans with the optimized parameters. Fractional anisotropy(FA) and average apparent diffusion coefficient (ADC) values were measured. The differences of FA and ADC values between liver healthy region and HCC lesion were compared through paired t tests. There were no significant changes in liver IQ and FA/ADC values with increased NED(P >0.05), whereas the liver IQ and FA/ADC values decreased significantly with increased b-values(P <0.05). Good IQ, acceptable scan time and reasonable FA/ADC values were acquired using NED = 9 with b-value of (0,300) s/mm2. Using the optimized DTI sequence, ADC value of the tumor lesion was significantly lower than that of the healthy liver region (1.30 ± 0.34×10-...Continue Reading

References

Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
May 1, 2001·Journal of Magnetic Resonance Imaging : JMRI·K M HasanA L Alexander
Jul 20, 2001·AJR. American Journal of Roentgenology·K M GauvainR J Hayashi
Jul 29, 2003·NMR in Biomedicine·Yvan BoulangerViviane Nicolet
Mar 21, 2007·Magnetic Resonance Imaging·Mikael SkorpilAnders Nordell
May 23, 2007·AJR. American Journal of Roentgenology·Dow-Mu Koh, David J Collins
Jun 27, 2008·Journal of Magnetic Resonance Imaging : JMRI·Bachir TaouliValérie Vilgrain
May 22, 2009·AJR. American Journal of Roentgenology·Nadja SaupeMarshall S Sussman
Aug 26, 2009·World Journal of Gastroenterology : WJG·Il Young KimYoung Tong Kim
Nov 26, 2009·Biochimica Et Biophysica Acta·Andriy Marusyk, Kornelia Polyak
Mar 5, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Anshul BagadiaSantosh Gupta
Jul 1, 2011·Journal of Clinical Gastroenterology·Susanne BonekampIhab R Kamel
Apr 24, 2012·European Journal of Radiology·Roman GuggenbergerGustav Andreisek
Sep 18, 2013·Acta Radiologica·Sukru Mehmet ErturkMuzaffer Basak
Nov 14, 2013·Journal of Magnetic Resonance Imaging : JMRI·Xing Hui LiNan Lin Zeng
Apr 16, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yunjung Lee, Hyeonjin Kim

❮ Previous
Next ❯

Citations

Nov 9, 2017·Contrast Media & Molecular Imaging·Gigin LinJae Mo Park
Sep 14, 2018·World Journal of Clinical Cases·Xing-Hui LiXiao-Ming Zhang
Apr 30, 2021·Japanese Journal of Radiology·Ahmed Abdel Khalek Abdel RazekTarek Elsayed Barakat
Jul 3, 2021·Journal of Clinical Medicine·Liberatore TramontanoValentina Brancato

❮ Previous
Next ❯

Methods Mentioned

BETA
through

Software Mentioned

Advantage Workstation
Minitab17

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.