Preliminary study on the development of nanoemulsions for carbamazepine intravenous delivery: an investigation of drug polymorphic transition

Drug Development and Industrial Pharmacy
Regina G KelmannLetícia S Koester

Abstract

Carbamazepine (CBZ) is available on the pharmaceutical market as tablets, capsules, and oral suspensions, but not as a parenteral formulation for clinical use. Parenteral emulsions are a good alternative to poorly water-soluble drugs such as CBZ. In this way, four different emulsions containing 3 mg/mL of CBZ were developed, but during a period of storage, drug crystal precipitates appeared. To investigate this phenomenon, differential scanning calorimetry, infrared spectroscopy, and light microscopy were employed. The results suggested a polymorphic transition from beta form to dehydrate form, resulting in drug precipitation, although the emulsions themselves remained stable for at least three months.

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Citations

Nov 7, 2009·Journal of Pharmaceutical Sciences·Harry G Brittain
Mar 15, 2015·Indian Journal of Pharmaceutical Sciences·A J RajammaA M Karthik
Aug 28, 2015·Drugs·Eugen TrinkaFrancesco Brigo
May 8, 2009·Analytical Chemistry·R K Gilpin, C S Gilpin

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