Preliminary Suggestion about Staging of Anorectal Malignant Melanoma May Be Used to Predict Prognosis

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Won Young ChaeJin Cheon Kim

Abstract

Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome. This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems. The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups: IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS: IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS: IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001). The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases.

References

Oct 1, 1990·Diseases of the Colon and Rectum·S GoldmanL Påhlman
Jan 1, 1986·The British Journal of Surgery·M W WardR J Nicholls
Oct 1, 1982·Diseases of the Colon and Rectum·P H CooperM S Allen
Feb 1, 1995·Diseases of the Colon and Rectum·M S BradyS H Quan
Jul 1, 1993·International Journal of Colorectal Disease·P M AntoniukV W Fazio
Dec 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R M Roumen
Aug 1, 1996·Surgical Oncology·P Luna-PerezS Labastida
Nov 27, 1998·Acta Oncologica·K BujkoP Liszka-Dalecki
Sep 25, 1999·Diseases of the Colon and Rectum·B CagirR D Fry
May 3, 2000·Histopathology·S S Banerjee, M Harris
Feb 22, 2003·Journal of the American College of Surgeons·Kelli M BullardMichael P Spencer
Sep 28, 2004·The British Journal of Surgery·P PessauxP Lasser
Jul 18, 2008·International Journal of Colorectal Disease·Satoshi IshizoneShinichi Miyagawa
Dec 17, 2009·The British Journal of Surgery·P J Nilsson, B K Ragnarsson-Olding
Oct 5, 2010·Journal of Gastrointestinal Cancer·Rhizlane BelbarakaHassan Errihani
Mar 8, 2012·Annals of Surgical Oncology·Koen TalsmaBas P L Wijnhoven
May 24, 2013·Journal of the American College of Surgeons·Claudius FalchBjörn L D M Brücher

❮ Previous
Next ❯

Citations

Feb 19, 2020·Future Oncology·Hari MenonVivek Verma
May 10, 2019·Abdominal Radiology·David D B BatesIva Petkovska

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Pucciarelli Lise
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Mathieu LuyckxDenis Querleu
© 2021 Meta ULC. All rights reserved