Preload-responsive, pulsatile-flow, externally valved pump: cardiopulmonary bypass

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
T M RungeS E Ottmers

Abstract

Currently two pumps are used for cardiopulmonary bypass, the roller pump and the centrifugal or vortex pump. Both are steady-flow pumps. The procedure of cardiopulmonary bypass possesses a finite morbidity and mortality. The degree to which steady flow is responsible for this morbidity and mortality remains to be clarified, but investigators have established the fact that a physiologic degree of pulsatile flow must be achieved before its beneficial results, such as normal systemic resistance and absence of lactate production, can be demonstrated. Availability of a satisfactory pulsatile pump for cardiopulmonary bypass has been a problem in the past but the pump presented here may satisfy this need. It produces physiologic pulsatility with rate dependent ejection time equal to or less than that of humans (413 microseconds minus 1.7 times heart rate), and it is preload-responsive, varying its pumping rate and output with filling pressure. The pump is externally valved to minimize hemolysis, which has been demonstrated in two laboratory studies to be significantly less than with the roller pump. It produces pulsatile flow through membrane oxygenators. The pump is thought to have potential for several clinical applications in addit...Continue Reading

References

Feb 1, 1985·World Journal of Surgery·G P NoonM E DeBakey
Oct 1, 1966·Archives of Surgery·R L Hewitt, O Creech
Jul 1, 1967·American Journal of Surgery·C W HallM E De Bakey
Dec 1, 1967·The American Journal of Physiology·I Ninomiya, H Irisawa
Jul 11, 1953·British Medical Journal·D G MELROSE
Feb 22, 1965·JAMA : the Journal of the American Medical Association·I MANDELBAUM, W H BURNS

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Citations

Apr 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·A H Stammers

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