Preludes to brain failure: executive dysfunction and gait disturbances

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Manuel Montero-Odasso, Vladimir Hachinski

Abstract

The progressive and insidious gait and cognitive decline seen in older individuals without overt disease may result from a combination of age-dependent neuronal changes that are often exacerbated by vascular pathomechanisms. Emerging evidence suggests that slow gait and executive dysfunction are early phenomena in this decline and may further evolve to the development of falls and dementia. These early manifestations can be seen as "brain failure" and their co-occurrence suggests that they may share a common underlying mechanism. The authors argue that brain cortical control of motor and gait performance; and high complex cognitive functions such as executive function, share the same brain networks. Due to its particular watershed vascularization, these brain networks are highly susceptible to microvascular damage and the effects of vascular risk factors. A unified approach for evaluating and treating these two features of aging will close the gap in our understanding of cognitive-motor interactions and ultimately alter the pathways to disability. Besides the standard treatment for cognitive and mobility decline, the authors suggest that treating reversible vascular risk factors and hypertension, especially when they represent ...Continue Reading

References

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Citations

May 3, 2014·Clinical Interventions in Aging·Anokha PadubidriMukaila A Raji
Nov 27, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Montero-Odasso
Mar 18, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Manuel M Montero-OdassoJennie L Wells
Oct 22, 2015·Neuropsychological Rehabilitation·Bradford J McFadyenMarie-Christine Ouellet
May 26, 2017·Age and Ageing·Jacqueline Kathleen KueperManuel Montero-Odasso
Feb 2, 2017·Journal of Neuroengineering and Rehabilitation·Bernard AuvinetVincent Goeb
Dec 20, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Montero-OdassoS W Muir-Hunter
Jul 20, 2019·Journal of Alzheimer's Disease : JAD·Stephanie CullenManuel Montero-Odasso
Jul 6, 2019·Scandinavian Journal of Medicine & Science in Sports·André Luiz Torres PirauáRodrigo Cappato de Araújo
Sep 4, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Manuel Montero-OdassoSusan W Muir-Hunter
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Manuel Montero-Odasso, George Perry
Jun 20, 2020·Age and Ageing·Manuel Montero-OdassoUNKNOWN Canadian Gait and Cognition Network
Sep 12, 2020·PloS One·Jacqueline K KueperUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 3, 2018·Journal of the American Geriatrics Society·Manuel Montero-OdassoUNKNOWN Canadian Gait and Cognition Network
Aug 14, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Manuel Montero-OdassoUNKNOWN Canadian Gait and Cognition Network
Dec 17, 2016·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Alexander BarthGabriele Doblhammer
Feb 7, 2017·Frontiers in Aging Neuroscience·Céline PolettiJean-Jacques Temprado
Jan 13, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaojing WangKai Wang
Jan 10, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erica FigginsManuel Montero-Odasso
Oct 24, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Manuel Montero-OdassoRichard Camicioli
Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci
Sep 17, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hanna JokinenSusanna Melkas

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