Premature brain aging in humans exposed to maternal nutrient restriction during early gestation

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Katja FrankeSusanne R de Rooij

Abstract

Prenatal exposure to undernutrition is widespread in both developing and industrialized countries, causing irreversible damage to the developing brain, resulting in altered brain structure and decreased cognitive function during adulthood. The Dutch famine in 1944/45 was a humanitarian disaster, now enabling studies of the effects of prenatal undernutrition during gestation on brain aging in late adulthood. We hypothesized that study participants prenatally exposed to maternal nutrient restriction (MNR) would demonstrate altered brain structure resembling premature brain aging in late adulthood, expecting the effect being stronger in men. Utilizing the Dutch famine birth cohort (n = 118; mean age: 67.5 ± 0.9 years), this study implements an innovative biomarker for individual brain aging, using structural neuroimaging. BrainAGE was calculated using state-of-the-art pattern recognition methods, trained on an independent healthy reference sample, then applied to the Dutch famine MRI sample, to evaluate the effects of prenatal undernutrition during early gestation on individual brain aging in late adulthood. Exposure to famine in early gestation was associated with BrainAGE scores indicative of an older-appearing brain in the male...Continue Reading

Citations

Feb 2, 2019·The Journal of Endocrinology·Miguel A VelazquezAdam J Watkins
May 31, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Anastasia Z KaleaJessica L Buxton
Sep 19, 2019·Nature Reviews. Neurology·Annabel K Short, Tallie Z Baram
Aug 30, 2020·Journal of Epidemiology and Community Health·Hongguo RongHai Fang
Jun 13, 2018·Molecular Psychiatry·James H ColeIan J Deary
Sep 3, 2019·Frontiers in Neurology·Katja Franke, Christian Gaser
Nov 19, 2020·Scientific Reports·Arinbjörn KolbeinssonIoanna Tzoulaki
Feb 1, 2020·Neuroscience and Biobehavioral Reviews·Katja FrankeMatthias Schwab
Feb 27, 2021·Frontiers in Human Neuroscience·Flavia M WehrleOskar G Jenni
May 6, 2021·International Journal of Environmental Health Research·Susanne R De RooijTessa J Roseboom
Jul 26, 2021·Trends in Neurosciences·Elena J L Coley, Elaine Y Hsiao
Oct 23, 2021·Frontiers in Aging Neuroscience·Nicolas CherbuinChristian Gaser

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