PMID: 1197785Sep 1, 1975Paper

Premature labor and indomethacin

Prostaglandins
N WigvistK Gréen

Abstract

Women in the 29th - 32nd week of gestation were admitted to hospital following the onset of premature labor contractions. After treatment with bed rest and beta-stimulating drugs, those patients with persistent uterine contractions were treated with oral indomethacin (25 mg every 6 hours for 5 days). The effect of indomethacin therapy was monitored by serial external tocometry recordings. This treatment schedule with indomethacin was repeated on several occasions at intervals of 5 to 10 days. Using a standardized technique, uterine contractility was monitored every second or third day throughout the entire treatment period. In this way, the frequency of contractions was evaluated in the presence or absence of indomethacin therapy. Following indomethacin treatment, there was a significant decrease in the frequency of contractions in all cases and a complete arrest of contractions occurred in some women. An increased frequency of contractions was observed during those times that the patient did not receive indomethacin. The plasms concentration of 15-keto-13, 14-dihydro-PGF2alpha, the major serum metabolite of PGF2alpha, was determined by the gas chromatography - mass spectrometry method before and after indomethacin in a limited...Continue Reading

References

Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·N Wiqvist
Jul 1, 1969·The Journal of Pediatrics·R A ArcillaK Ranniger
Dec 1, 1974·Obstetrics and Gynecology·H ZuckermanI Rubinstein
Nov 1, 1972·Biochemical and Biophysical Research Communications·M Hamberg
Feb 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M J KeirseA C Turnbull
Jan 1, 1965·Acta Obstetricia Et Gynecologica Scandinavica·L Lindgren, N Fagerlund
Apr 1, 1967·The Journal of Obstetrics and Gynaecology of the British Commonwealth·S M Karim, J Devlin

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Citations

Feb 1, 1979·Prostaglandins and Medicine·B H Vickery
Jun 16, 1986·European Journal of Biochemistry·S Krüger, W Schlegel
May 1, 1977·British Journal of Obstetrics and Gynaecology·H ZuckermanD Sklan
Jan 24, 1987·British Medical Journal·M A Byron
Jul 1, 1978·The Journal of Clinical Investigation·J G GerberA S Nies
Apr 1, 1981·British Journal of Obstetrics and Gynaecology·S M SellersA C Turnbull
Aug 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Z KatzH Ben Hur
Jan 1, 1983·Archives of Gynecology·H P Schneider, W Schlegel

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