Premature luteinization: could it be an early manifestation of low ovarian reserve?

Fertility and Sterility
Johnny S YounisM Ben-Ami

Abstract

To gain insight into the physiologic significance of premature luteinization and to evaluate whether it could be a manifestation of low ovarian reserve. Retrospective evaluation. Reproductive medicine unit. Thirty-one consecutively seen women with normal ovulation and unexplained infertility. Induction of superovulation with hMG coupled with synchronized IUI. A GnRH agonist was not used during the study. Premature luteinization was defined as a progesterone/estradiol ratio of > 1 on the day of hCG administration. Patients were evaluated during their first cycles of hMG treatment and then were divided into those with (study group) and those without (control group) premature luteinization. The ovarian reserve parameters were compared between the two groups. Nineteen of the 31 patients with unexplained infertility demonstrated premature luteinization. Patient characteristics were similar between the study and control groups. Mean (+/- SD) day 3 FSH levels were 8.2 +/- 3.3 and 6.6 +/- 1.7 mIU/mL in the study and control groups, respectively. Mean (+/- SD) day 3 estradiol levels were significantly higher in the study than in the control group (74 +/- 49 pg/mL vs. 30 +/- 17 pg/mL, respectively). Mean (+/- SD) estradiol levels on the ...Continue Reading

Citations

Oct 29, 2009·Archives of Gynecology and Obstetrics·Esra Bulgan KiliçdagTayfun Bagis
May 22, 2009·Journal of Assisted Reproduction and Genetics·Hisham Ali SalehMohamed Draz
May 27, 2011·Journal of Assisted Reproduction and Genetics·Johnny S Younis
Sep 13, 2003·Fertility and Sterility·Johnny S Younis
Apr 25, 2000·Molecular and Cellular Endocrinology·A P FerrarettiN Colacurci
Aug 29, 2009·Reproductive Biomedicine Online·J Martinez-SalazarJ A Garcia-Velasco
Dec 14, 2004·Reproductive Biomedicine Online·L MorenoJ A Garcia-Velasco
Feb 23, 2012·Molecular Human Reproduction·Christine C SkiadasCatherine Racowsky
Oct 18, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Johnny S YounisGalit Sarig
Jun 14, 2014·Reproductive Biomedicine Online·Charlotte SonigoJean-Noel Hugues
Aug 13, 2015·The Journal of Endocrinology·Yan-Guang WuNorbert Gleicher
Mar 1, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Joan-Carles ArceAntonio La Marca
Jun 15, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Johnny S YounisMoshe Ben-Ami
Nov 7, 2015·Reproductive Biology and Endocrinology : RB&E·E Shalom-PazA Ellenbogen
Jul 4, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ritika AroraEllen M Greenblatt
Sep 26, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Pieraldo InaudiStefano Luisi
Oct 28, 2019·Journal of Assisted Reproduction and Genetics·Reda S HusseinYulian Zhao

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