Premature or Small for Gestational Age Discrimination: International Multicenter Trial Protocol for Classification of the Low-Birth-Weight Newborn Through the Optical Properties of the Skin

JMIR Research Protocols
Zilma Silveira Nogueira ReisRoberta Romanelli

Abstract

A low birth weight is an independent risk factor for adverse infant outcomes and a predictor of chronic disease in adulthood. In these situations, differentiating between prematurity and small for gestational age (SGA) or simultaneous conditions is essential to ensuring adequate care. Such diagnoses, however, depend on reliable pregnancy dating, which can be challenging in developing countries. A new medical optoelectronic device was developed to estimate gestational age (GA) at birth based on newborn skin reflection. This study will aim to evaluate the device's ability to detect prematurity or SGA, or both conditions simultaneously as well as predict short-term pulmonary complications in a cohort of low-birth-weight newborns. This study protocol was designed for a multicenter cohort including referral hospitals in Brazil and Mozambique. Newborns weighing 500-2500 g will be eligible for inclusion with the best GA available, considering the limited resources of low-income countries. Comparator-GA is based on reliable last menstrual period dating or ultrasound assessment before 24 weeks' gestation. Estimated GA at birth (Test-GA) will be calculated by applying a novel optoelectronic device to the newborn's skin over the sole. The...Continue Reading

References

Jul 1, 1981·The Journal of Investigative Dermatology·R R Anderson, J A Parrish
Aug 1, 1997·Photodermatology, Photoimmunology & Photomedicine·J Lock-AndersenH C Wulf
May 5, 2000·The Cochrane Database of Systematic Reviews·R F Soll
Jun 1, 2000·Obstetrics and Gynecology·T H NguyenH Møller
Sep 3, 2004·American Journal of Obstetrics and Gynecology·Thomas J GariteJames A Thorp
Jul 16, 2005·Journal of Clinical Epidemiology·Antoine FlahaultGuy Thomas
Nov 13, 2008·Paediatric and Perinatal Epidemiology·Caroline S HoffmanKatherine E Hartmann
Jul 12, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·Z A BhuttaUNKNOWN International Fetal and Newborn Growth Consortium for the 21st Century
Jan 1, 2013·Reproductive Health·Christopher P HowsonUNKNOWN Born Too Soon Preterm Birth Action Group
Jul 22, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A T PapageorghiouJ Villar
Oct 3, 2014·Pediatrics in Review·Suzanne ReuterMichelle Baack
Nov 2, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Francesc FiguerasEduard Gratacos
Dec 15, 2015·JAMA : the Journal of the American Medical Association·Lawrence O Gostin, Eric A Friedman
Mar 1, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A T PapageorghiouUNKNOWN International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st)
Dec 13, 2016·EBioMedicine·Kumanan WilsonJulian Little
Mar 28, 2017·American Journal of Obstetrics and Gynecology·Montse PalacioUNKNOWN Fetal Lung Texture Team
Jun 12, 2017·Radiologic Clinics of North America·Mark C LiszewskiEdward Y Lee
Nov 6, 2018·The Lancet Global Health·Anne Cc LeeJoy E Lawn
Apr 16, 2020·JMIR Pediatrics and Parenting·Zilma Silveira Nogueira ReisRegina Amélia Lopes Pessoa Aguiar

❮ Previous
Next ❯

Methods Mentioned

BETA
SGA
contraception
light scattering
X-ray

Software Mentioned

GA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved