PMID: 9526706Apr 4, 1998Paper

Premature ovarian failure: steroid synthesis and autoimmunity

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
N DoldiA Ferrari

Abstract

The androgen biosynthesis and autoimmunity of 25 patients with premature ovarian failure (POF) and 18 control subjects with normal cycles were examined. Serum levels of dehydroepiandrosterone sulfate (DHEAS), 17-hydroxyprogesterone (17-OHP), androstenedione, and testosterone were analyzed in POF patients with or without organ-specific autoimmunity, and the results compared with those of women with normal ovarian function. The comparative analysis of DHEAS, 17-OHP, androstenedione and testosterone showed that POF patients had significantly lower values than normal women (DHEAS, androstenedione and testosterone p < 0.01, 17-OHP p < 0.05). Furthermore, we found one or more organ-specific autoantibodies in 11 patients with POF (44%), while only one woman in the control group showed autoimmunity (antithyroid microsome) (5.5%). Only one patient had both anti-ovarian and anti-adrenal antibodies (4%). The comparison of androgen levels in POF patients with or without autoimmunity revealed a statistically significant reduction of DHEAS levels in POF patients with organ-specific autoimmunity (p < 0.01). These data reveal the reduction in androgen synthesis in POF patients, particularly in those with organ-specific autoimmunity.

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Citations

May 4, 2005·Fertility and Sterility·Lawrence M NelsonRobert W Rebar
May 15, 2002·Fertility and Sterility·Susan R Davis
Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Judith Luborsky
Jul 1, 2007·Women's Health·Alessandra Graziottin
Mar 17, 2007·Climacteric : the Journal of the International Menopause Society·T A Nippita, R J Baber
Mar 10, 2016·Fertility and Sterility·Stefano StagiMaurizio de Martino
Mar 1, 2003·Clinical Endocrinology·Sonia Davison, Susan R Davis
Aug 27, 2010·Annals of the New York Academy of Sciences·Michael L Traub, Nanette Santoro
Feb 12, 2005·Fertility and Sterility·Cristina Laguna Benetti-PintoLuís Alberto Magna
May 6, 2015·Nature Reviews. Endocrinology·Aya Shohat-TalNorbert Gleicher
May 15, 2016·Annals of Vascular Surgery·Kennedy Gonçalves Pacheco, Maria Raquel Fortes de Oliveira
Oct 31, 2006·Fertility and Sterility·Sophia N KalantaridouLawrence M Nelson
Jul 12, 2018·Menopause : the Journal of the North American Menopause Society·Midhun SomanXiao-Ming Zhu
May 15, 2007·Hormone Research·Deepti Goswami, Gerard S Conway
Feb 8, 2008·Menopause : the Journal of the North American Menopause Society·Jolande G van der StegeAnnemieke Hoek
May 6, 2005·Treatments in Endocrinology·Mary-Anne Papalia, Susan R Davis
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Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Sophia N KalantaridouLawrence M Nelson
Feb 2, 2021·Climacteric : the Journal of the International Menopause Society·S R Davis

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