Premature ovarian insufficiency: Pathogenesis and management

Journal of Mid-life Health
Anna J Fenton

Abstract

The term premature ovarian insufficiency (POI) describes a continuum of declining ovarian function in a young woman, resulting in an earlier than average menopause. It is a term that reflects the variable nature of the condition and is substantially less emotive than the formerly used "premature ovarian failure" which signaled a single event in time. Contrary to the decline in the age of menarche seen over the last 3-4 decades there has been no similar change in the age of menopause. In developed nations, the average age for cessation of menstrual cycles is 50-52 years. The age is younger among women from developing nations. Much has been written about POI despite a lack of good data on the incidence of this condition. It is believed that 1% of women under the age of 40 years and 0.1% under the age of 30 years will develop POI. Research is increasingly providing information about the pathogenesis and treatments are being developed to better preserve ovarian function during cancer treatment and to improve fertility options. This narrative review summarizes the current literature to provide an approach to best practice management of POI.

References

Sep 1, 1985·Annals of Internal Medicine·S M McKinlayJ B McKinlay
Oct 1, 1996·Journal of Clinical Epidemiology·L J MeltonW M O'Fallon
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Apr 17, 2003·Maturitas·Dimitrios J HadjidakisSotirios A Raptis
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D J M van Der VoortR Barentsen
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marjolein van der KliftHuibert A P Pols
Mar 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Joanne M MurabitoL Adrienne Cupples
Jun 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Cynthia M FarquharAlistair W Stewart
Jan 4, 2007·Neurology·M Alonso de LeciñanaUNKNOWN PIVE Study Investigators of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group
May 23, 2008·Maturitas·C M FrancucciM Boscaro
Jun 25, 2008·Annals of the New York Academy of Sciences·Joe Leigh Simpson
Feb 24, 2009·Stroke; a Journal of Cerebral Circulation·Lynda D LisabethPhilip A Wolf
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Murat Api
Oct 23, 2010·Obstetrics and Gynecology·Melissa M Hudson
Dec 28, 2010·European Heart Journal·Erik IngelssonDaniel Altman
Jan 13, 2011·Molecular Reproduction and Development·Fumio OtsukaShunichi Shimasaki
May 7, 2011·Climacteric : the Journal of the International Menopause Society·T YoshidaH Kurachi
Oct 14, 2011·Menopause : the Journal of the North American Menopause Society·Walter A RoccaRobert D Brown
Jan 10, 2012·Climacteric : the Journal of the International Menopause Society·Anna Fenton, Nick Panay
Jan 25, 2012·Climacteric : the Journal of the International Menopause Society·C AtabekoğluM Sönmezer
May 2, 2012·Menopause : the Journal of the North American Menopause Society·Kimberly K VescoUNKNOWN Study of Osteoporotic Fractures
Jun 14, 2012·Menopause : the Journal of the North American Menopause Society·Melissa WellonsDhananjay Vaidya
Jul 6, 2012·Climacteric : the Journal of the International Menopause Society·Nick Panay, Anna Fenton
Jul 17, 2012·Critical Reviews in Oncology/hematology·F Y F L De VosA Jager
Mar 16, 2013·Climacteric : the Journal of the International Menopause Society·T J de VilliersM Rees
Dec 18, 2013·Climacteric : the Journal of the International Menopause Society·J Ben-Nagi, N Panay
Mar 5, 2014·International Journal of Women's Health·Leticia Cox, James H Liu
Oct 22, 2014·European Journal of Preventive Cardiology·Jeanine E Roeters van LennepUNKNOWN collaborators of the Dutch Multidisciplinary Guideline Development Group on Cardiovascular Risk Management after Reproductiv
Jan 19, 2015·Journal of Endocrinological Investigation·S LuisiF Petraglia
Apr 8, 2015·Climacteric : the Journal of the International Menopause Society·S S FaubionW A Rocca
May 16, 2015·The Journal of Clinical Endocrinology and Metabolism·Stine Aa LundingAnette T Pedersen

❮ Previous
Next ❯

Citations

Jul 6, 2016·The Indian Journal of Medical Research·Claudio Hernández-Angeles, Camil Castelo-Branco
Aug 23, 2016·Fertility and Sterility·Erika T Chow, Shruthi Mahalingaiah
Jul 1, 2017·Expert Opinion on Drug Safety·James H PickarHugh S Taylor
Apr 7, 2017·Post Reproductive Health·Haitham Hamoda, UNKNOWN British Menopause Society and Women’s Health Concern
Mar 14, 2018·Menopause : the Journal of the North American Menopause Society·Xiao-Jing CaoXiao-Yun Wang
Jul 25, 2017·European Journal of Endocrinology·Annamaria De BellisUNKNOWN On the behalf of the Italian Addison Network
Dec 29, 2019·Biology of Reproduction·Gillian P Johnson, Kim Carol Jonas
Sep 12, 2020·Climacteric : the Journal of the International Menopause Society·O Y AlshogranM J Alkhatatbeh
May 18, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Muladili YuemaierXiamixinuer Yilike
Sep 22, 2020·World Journal of Stem Cells·Khadijeh BahrehbarHossein Baharvand
Jul 14, 2018·Frontiers in Endocrinology·Stine G Kristensen, Claus Y Andersen
Oct 24, 2018·Journal of Clinical Medicine·Agnieszka PodfigurnaBlazej Meczekalski
Oct 22, 2019·Post Reproductive Health·Dani Singer
May 28, 2021·Frontiers in Cell and Developmental Biology·Seung Joo ChonMee-Sup Yoon
Jun 7, 2021·BMC Pregnancy and Childbirth·Jiaman WuJilong Yao
Jun 23, 2021·Aging·Svetlana YurenevaGennady Sukhikh

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy
bilateral oophorectomy

Software Mentioned

Climacteric

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.