Premature red blood cells have decreased aggregation and enhanced aggregability

The Journal of Physiological Sciences : JPS
D ArbellS Yedgar

Abstract

Preterm infants are highly susceptible to ischemic damage. This damage is most obvious in the brain, retina, and gastrointestinal tract. Studies focusing on the rheological properties of premature red blood cells (pRBCs) have consistently shown minimal or no RBC aggregation. Previously, measurements of pRBC aggregation kinetics indicated that specific plasma properties are responsible for the decreased RBC aggregation observed in the neonates, but that their specific RBC properties do not affect it. However, the strength of interaction in the pRBC aggregates as a function of medium composition has not been tested. In our previous research, we described clinically relevant parameters, that is, the aggregate resistance to disaggregation by flow. With the help of a cell flow property analyzer (CFA), we can monitor RBC aggregation by direct visualization of its dynamics during flow. We used the CFA to examine pRBC (from 9 premature babies) in the natural plasma and in PBS buffer supplemented with dextran (500 kDa) to distinguish between RBC intrinsic-cellular and plasma factors. pRBCs suspended in the native plasma showed minimal or no aggregation in comparison to normal adult RBC. When we transferred pRBCs from the same sample to ...Continue Reading

References

May 1, 1989·Microvascular Research·A Stadler, O Linderkamp
Sep 1, 1987·Baillière's Clinical Haematology·O Linderkamp
Dec 1, 1984·Pediatric Research·O LinderkampH J Meiselman
Jan 16, 1999·Pediatric Research·P Ruef, O Linderkamp
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R B AmiS Yedgar
Jul 19, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ronen Ben-AmiShlomo Berliner
Jun 15, 2005·Schizophrenia Bulletin·Gregory BarshteinLev D Bergelson
Jul 4, 2007·Expert Review of Cardiovascular Therapy·Gregory BarshteinSaul Yedgar

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Citations

Feb 6, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dan ArbellSaul Yedgar

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