Premature senescence of T lymphocytes from patients with beta-thalassemia major

Immunology Letters
Marjan GharagozlooBehjat Moayedi

Abstract

Several researches have demonstrated a suppressed cell mediated immunity in patients with beta-thalassemia major. To know whether the premature aging of T cells is involved in abnormalities of cell mediated immunity, the biomarkers of immunosenescence including telomerase activity, apoptosis, and the expression of CD28 and CD95 were evaluated in T lymphocytes from beta-thalassemia major patients. The ex vivo spontaneous apoptosis in CD4(+) or CD8(+) T cells from patients and healthy subjects was assessed by an in situ TdT mediated dUTP-biotin nick end labelling (TUNEL) assay after 24h incubation in medium. Flow cytometric data revealed that lymphocytes from beta-thalassemia patients were resistant to spontaneous apoptosis compared to the normal lymphocytes. Moreover, the percentages of TUNEL(+)CD4(+) or TUNEL(+)CD8(+) T cells from patients were significantly lower than those control cells. Quantitative determination of telomerase activity in resting and activated T cells was performed using the Telomeric Repeat Amplification Protocol (TRAP). The results showed a decreased telomerase activity of activated T cells in patients with thalassemia major compared to that in healthy controls. However, the percentages of CD8(+)CD28(-) an...Continue Reading

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Citations

Jun 16, 2010·Immunity & Ageing : I & a·Joseph Ongrádi, Valéria Kövesdi
Jun 20, 2014·Immunopharmacology and Immunotoxicology·Sima BalouchiBehjat Moayedi
Mar 20, 2015·Archives of Toxicology·Kazuyuki Okamura, Keiko Nohara
Apr 30, 2013·International Immunopharmacology·Marjan GharagozlooZahra Amirghofran
Oct 30, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Batoul PourgheysariSoleiman Kheiri
Jan 18, 2017·Frontiers in Immunology·Fernando A ArosaElsa M Cardoso

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