PMID: 8972253Oct 1, 1996Paper

Premature separation of centromere and aneuploidy: an indicator of high risk in unaffected individuals from familial breast cancer families?

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
N M RaoS N Ghosh

Abstract

It is estimated that one in every four women with a first-degree relative affected by breast cancer will develop the disease. Recent evidence suggests that susceptibility to breast cancer can be inherited. We have carried out cytogenetic analysis on PHA-stimulated lymphocyte cultures of breast cancer patients (familial and sporadic), patients with benign breast lesions, unaffected individuals from families with a history of breast cancer and healthy controls. A high incidence of premature separation of centromere (PSC) and aneuploidy was observed in a significant proportion of familial breast cancer patients and patients with fibrocystic disease as well as in some unaffected individuals from breast cancer families. These observations are also supported by cytogenetic analysis of EBV-transformed lymphoblastoid cell lines established from some of these individuals. No such aberrations were detected in the controls. Further, most of the affected and unaffected individuals with these two anomalies also exhibited structural chromosomal aberrations of 1q, 6q, 7q, 16q, 18q, or Xq. Based on these observations, we propose that the presence of both PSC and aneuploidy in lymphocyte cultures of unaffected individuals from breast cancer fam...Continue Reading

Citations

Aug 20, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Paola CastronovoLidia Larizza
Mar 17, 2012·Dose-response : a Publication of International Hormesis Society·Yasir Hasan SiddiqueMohammad Afzal
Dec 7, 2006·Oncology Nursing Forum·Na-Jin Park, Duck-Hee Kang
Jan 23, 1999·American Journal of Medical Genetics·C LimwongseN H Robin
Aug 16, 2005·American Journal of Medical Genetics. Part a·Maninder KaurIan D Krantz

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