Premeal Low-Fat Yogurt Consumption Reduces Postprandial Inflammation and Markers of Endotoxin Exposure in Healthy Premenopausal Women in a Randomized Controlled Trial

The Journal of Nutrition
Ruisong PeiBradley W Bolling

Abstract

Metabolic endotoxemia is associated with obesity and contributes to postprandial inflammation. We aimed to determine if low-fat yogurt consumption prevents postprandial inflammation and dysmetabolism in healthy women by inhibiting biomarkers of metabolic endotoxemia. Premenopausal women defined as obese and nonobese [body mass index (BMI, in kg/m2) 30-40 and 18.5-27, respectively, n = 120] were randomly assigned to consume 339 g of low-fat yogurt (YN, yogurt nonobese; YO, yogurt obese) or 324 g of soy pudding (CN, control nonobese; CO, control obese) for 9 wk (n = 30/group). The intervention foods each supplied 330 kcal with 3 g fat, 66 g carbohydrate, and 4-6 g protein. At weeks 0 and 9, participants ingested 226 g of yogurt or 216 g of soy pudding before a meal providing 56-60 g fat, 82 g carbohydrate, and 28-30 g protein. Plasma soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP), LPS activity, interleukin-6 (IL-6), glucose, triglyceride, and insulin were measured hourly for 4 h to assess differences in postprandial responses between groups by 2-factor ANOVA. Premeal yogurt consumption prevented the postprandial decrease in sCD14 net incremental area under the curve (net iAUC) by 72% in obese individuals at week 0...Continue Reading

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Citations

Sep 27, 2019·Advances in Nutrition·Kristin M HirahatakeSean H Adams
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Fatimo BiobakuParesh Dandona
Jan 7, 2021·Current Nutrition Reports·Leila Khorraminezhad, Iwona Rudkowska
Oct 12, 2021·Advances in Nutrition·Julie M HessBradley W Bolling

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