PMID: 5924Mar 1, 1976

Premedicant drugs and gastric juice pH and volume in pediatric patients

Anesthesiology
M R SalemT Toyama

Abstract

The effects of premedication on gastric juice volume and pH were evaluated in five groups of 206 pediatric patients undergoing elective surgical procedures: Group 1 (Control) received no premedication; Group 2 was given morphine sulfate and pentobarbital as premedicants. The other groups received, in addition to morphine and pentobarbital, atropine (Group 3), scopolamine (Group 4), or glycopyrrolate (Group 5). After endotracheal intubation, gastric aspirates were examined for volume, pH and color. Neither premedication with morphine and pentobarbital nor addition of atropine or scopolamine to the premedication significantly altered volume. In patients treated with glycopyrrolate, volume was reduced to less than a third of that of patients in Group 1 (P less than 0.001), and the percentage of pH's higher than 2.5 was significantly greater than in other groups. The incidences of unobtainable samples and samples with pH's higher than 2.5 were greatest with atropine (32.0 per cent, P less than 0.05) and glycopyrrolate (58.1 per cent, P less than 0.01). In 60 per cent of the bile-stained specimens, pH's were below 2.5. It is concluded that because of its selective inhibitory effect on gastric acid secretions, glycopyrrolate appears ...Continue Reading

Citations

May 1, 1988·Indian Journal of Pediatrics· InduB Saikia
Jan 1, 1981·Canadian Anaesthetists' Society Journal·A W GottaP L Goldiner
Jan 1, 1982·Canadian Anaesthetists' Society Journal·D M DewanL Rhyne
Jun 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K MikawaH Obara
May 1, 1986·Canadian Anaesthetists' Society Journal·R L McCammon
Mar 18, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·K ClarkD Currow
Jan 1, 1981·General Pharmacology·R K Mirakhur, J W Dundee
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·T RandellL Lindgren
Jul 2, 1999·Anesthesia and Analgesia·W M Splinter, M S Schreiner
May 13, 1999·Paediatric Anaesthesia·B J AndersonM J Wardill
Aug 13, 2010·Acta Anaesthesiologica Scandinavica·A G JensenClinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Dec 18, 1987·The American Journal of Medicine·T H Joyce
Aug 1, 1983·Acta Anaesthesiologica Scandinavica·M TrybaM Zenz
Jul 1, 1986·Acta Anaesthesiologica Scandinavica·B A SchurizekB Juhl
Jul 1, 1987·Acta Anaesthesiologica Scandinavica·N G Goudsouzian, E T Young
Jan 1, 1986·Acta Anaesthesiologica Scandinavica·U Aromaa, T Kalima
Dec 1, 1983·Anaesthesia·R K Mirakhur, J W Dundee
May 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T H Madej, R T Paasuke
Aug 1, 1977·Anaesthesia and Intensive Care·A J Newson
Nov 1, 1986·Anaesthesia and Intensive Care·J H van der Walt, J A Carter

Related Concepts

Atropen
Gastric Juice
Glycopyrrolate
Hydrogen-Ion Concentration
Morphine Sulfate (2: 1), Pentahydrate
Antispasmodic Effect
Diabutal
Preanesthetic Medication
Pyrrolidines
Scoburen

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