Premedication of pediatric tonsillectomy patients with oral transmucosal fentanyl citrate

Anesthesia and Analgesia
Richard M DsidaCharles J Coté

Abstract

We assessed the safety and efficacy of oral transmucosal fentanyl citrate (Fentanyl Oralet; Abbott Laboratories, Abbott Park, IL), administered preoperatively to provide both preoperative sedation and postoperative analgesia, in a randomized, double-blind, placebo-controlled study in 40 children, 2-10 yr of age, scheduled for tonsillectomy. In the preoperative holding area, one group (Group O) received Fentanyl Oralet (fentanyl 10-15 micrograms/kg), and the other (Group IV) received only the candy matrix. Patients in Group O received an i.v. injection of saline, and those in Group IV received an i.v. injection of fentanyl (2 micrograms/kg) after removal of the first tonsil. Except for the opioid, patients received a standard anesthetic. Preoperative sedation and cooperation were assessed. Postoperative pain was evaluated using an objective pain scale. Patients in Group O were more sedated but no more cooperative at the induction of anesthesia compared with those in Group IV. No patient vomited preoperatively or experienced preoperative or postoperative desaturation. Time to postanesthesia care unit (PACU) discharge was not different between groups. There was no significant difference in the number of patients requiring morphine...Continue Reading

References

Oct 14, 1977·European Journal of Clinical Pharmacology·M MichielsJ Heykants
Aug 1, 1991·Anesthesiology·J B StreisandT H Stanley
Jul 1, 1989·Anesthesia and Analgesia·J B StreisandN L Pace
Jul 1, 1980·Clinical Pharmacology and Therapeutics·D A McClain, C C Hug
Feb 1, 1994·Pediatric Clinics of North America·C J Coté
Dec 1, 1996·Anesthesiology·B GinsbergS L Shafer

❮ Previous
Next ❯

Citations

Jan 23, 2002·The Journal of Burn Care & Rehabilitation·S R ShararL A Lee
Feb 24, 2001·The Laryngoscope·C W GrossW D Spotnitz
Jun 29, 2006·Clinical Pharmacokinetics·Andrea N EdgintonStefan Willmann
Mar 24, 2009·Paediatric Drugs·Boris ZernikowBrian J Anderson
Apr 20, 2001·Journal of Pain and Symptom Management·S Mercadante, R K Portenoy
Sep 16, 2000·Journal of Pain and Symptom Management·D J Casarett, J H Karlawish
Sep 29, 2001·Journal of Pain and Symptom Management·B GagnonE D Bruera
Aug 23, 2001·Journal of Pain and Symptom Management·R PayneR K Portenoy
Mar 1, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·C Ecoffey
Oct 5, 2006·Current Opinion in Anaesthesiology·Z N Kain
Aug 13, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Robert P HunterDavid E Koch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.