PMID: 9166990Apr 1, 1997Paper

Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs

Basic Research in Cardiology
Lisa M SchwartzK A Reimer

Abstract

Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this paper were undertaken to determine whether the infarct-limiting effect of four 5-min episodes of ischemia interspersed by reperfusion can be achieved by a single 5-min episode. Adult open-chest mongrel dogs, premedicated with the analgesic butorphanol, and anesthetized with sodium pentobarbital, underwent occlusion of the circumflex coronary artery for 60 min, followed by reperfusion of 3 h. Treated dogs were preconditioned with one, two or four cycles of 5-min occlusion followed by reperfusion. Additional dogs, not premedicated with butorphanol, were either untreated (not preconditioned) or preconditioned with one cycle of ischemia. Infarcts were identified using triphenyl-tetrazolium chloride (TTC) macrochemistry and infarct size (as % of area-at-risk, AAR) was measured and analyzed (using analysis of covariance [ANCOVA]) with respect to coronary collateral blood flow (measured using radioactive microspheres). Four ...Continue Reading

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Citations

Dec 18, 2013·Interactive Cardiovascular and Thoracic Surgery·Yun WuYan-Lin Wang
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli
Oct 28, 2014·Medicinal Research Reviews·L TestaiV Calderone
Oct 20, 2004·Coronary Artery Disease·Koh KuzumeDonna M Van Winkle
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jonna R TerkildsenNicolas P Smith
Jun 15, 2007·Journal of Applied Animal Welfare Science : JAAWS·B Witkind DavisFrancisco Galindo
Jun 15, 2007·Journal of Applied Animal Welfare Science : JAAWS·William J Fielding
Sep 3, 2019·The Cochrane Database of Systematic Reviews·Brigid E HickeyMark Jeffery
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Daniel C SiggPaul A Iaizzo
Dec 22, 1999·The American Journal of Physiology·S BanerjeeR Bolli
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E KodaniR Bolli
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y T XuanR Bolli
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Lisa M SchwartzMark S Crago
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Buddhadeb DawnRoberto Bolli
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Eitaro KodaniRoberto Bolli

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