Premenstrual exacerbation of depressive disorders in a community-based sample in the United States

Psychosomatic Medicine
S Ann HartlageHoward M Kravitz

Abstract

No published epidemiologic study has examined premenstrual exacerbation of depressive disorders (PME-DD) in a representative sample. Knowledge gained should indicate the burden of illness, suggest whom to monitor, and facilitate diagnosis. The objectives were to 1) ascertain the prevalence and predictors of PME-DD; and 2) test competing hypotheses that PME-DD is related to a) severity or history of depression, b) menstrual cyclicity in females in general, or c) a methodological artifact. Menstruating females (N = 900) from ages 13 to 53 living in urban or rural Illinois completed semi-structured psychiatric diagnostic interviews and rated symptoms of depression daily for two menstrual cycles; 58 had major depressive, dysthymic, or subclinical depressive disorders, and the remaining 842 were the non-depressed portion of the representative sample. Depressed females had 1.34 (95% confidence interval, 1.02-1.66) symptoms exacerbated premenstrually. The best model for predicting exacerbation contained only age. Older women more often had symptoms worsen. Symptoms during the follicular phase were most severe for clinically depressed, intermediate for subclinically depressed, and least severe for non-depressed participants, ps < 0.001...Continue Reading

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Citations

Feb 24, 2006·Journal of Abnormal Psychology·Eynav Elgavish Accortt, John J B Allen
Apr 18, 2009·Harvard Review of Psychiatry·Joanne CunninghamElias Eriksson
Apr 14, 2010·The Psychiatric Clinics of North America·Simone N VigodMeir Steiner
Dec 1, 2009·Obstetrics and Gynecology Clinics of North America·Simone N VigodMeir Steiner
Jun 27, 2013·Journal of Affective Disorders·Eynav E AccorttJohn J B Allen
Oct 19, 2019·Current Psychiatry Reports·Jessica R Peters, Tory A Eisenlohr-Moul
Aug 8, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tara A LeGatesScott M Thompson
Oct 8, 2018·Current Psychiatry Reports·Sarah A Owens, Tory Eisenlohr-Moul
Oct 10, 2021·Current Psychiatry Reports·Christine Kuehner, Sibel Nayman

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