Premixed acidic calcium phosphate cement: characterization of strength and microstructure

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
J AbergH Engqvist

Abstract

By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste. As the paste does not contain water, no setting reaction starts and thus the working time is indefinite. Powder/liquid ratios (P/L) of 2.25, 3.5 and 4.75 were evaluated. Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction. The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST. Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa. The microstructure mainly consisted of monetite, 1-5 microm in grain size. After 4 weeks in PBS, the strength increased. As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements. Premixed cements ...Continue Reading

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Citations

Feb 9, 2013·Journal of Materials Science. Materials in Medicine·Jonas AbergHåkan Engqvist
Aug 6, 2013·Journal of Neurosurgery·Thomas EngstrandHåkan Engqvist
May 9, 2015·Materials Science & Engineering. C, Materials for Biological Applications·M MontazerolghaemA J Rasmusson
Aug 23, 2011·Acta Biomaterialia·Faleh TamimiJake Barralet
Mar 13, 2016·Journal of Materials Science. Materials in Medicine·M MontazerolghaemM Karlsson Ott
Feb 24, 2012·Journal of Biomedical Materials Research. Part a·J AbergH Brisby
Mar 28, 2013·Journal of Biomedical Materials Research. Part a·Maryam MontazerolghaemMarjam Karlsson Ott
Apr 26, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Johanna Engstrand UnossonHåkan Engqvist
Jul 16, 2011·International Journal of Biomaterials·Jonas AbergHåkan Engqvist
Jan 30, 2015·Journal of Materials Science. Materials in Medicine·Marc BohnerNicola Döbelin
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Seyed Mohammad Hossein DabiriLaura Pastorino
Apr 4, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Naoyuki FukudaKunio Ishikawa
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
Aug 31, 2015·Materials·Zeeshan SheikhMichael Glogauer
Apr 19, 2012·Journal of Tissue Engineering·Roman A PerezMaria-Pau Ginebra
Feb 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·G CamaS Deb
Jun 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Erdem Şahin, Muhsin Çiftçioğlu

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