Premorbid intra-individual variability in intellectual performance and risk for schizophrenia: a population-based study

Schizophrenia Research
Abraham ReichenbergMichael Davidson

Abstract

Some, but not most, schizophrenia patients have below-average intelligence years before they manifest psychosis. However, it is not clear if those whose intelligence falls within-normal-range nevertheless have cognitive abnormalities. We examined the association between intra-individual variability in intellectual performance and risk for schizophrenia in individuals with normal IQ. 555,326 adolescents, mandatory assessed by the Israeli Draft Board were followed up over 8 to 17 years for psychiatric hospitalization by means of the Israeli National Psychiatric Hospitalization Case Registry. Data were available on 4 intelligence sub-tests, and on behavioral and psychosocial variables. Variability was computed from the variance of the four intelligence tests' standardized scores. There was a significant monotonic association between increased intra-individual variability in intellectual performance and risk of schizophrenia in individuals with within-normal-range IQ. Individuals with the highest variability were 3.8 times more likely to have schizophrenia [95%CI: 2.32-6.08; p < 0.0001] compared with individuals with the lowest variability. This association held after controlling for the effects of potential confounders. Despite wi...Continue Reading

Associated Clinical Trials

Aug 17, 2015·Margaret McNamara McClure

Citations

Feb 4, 2014·Journal of Immigrant and Minority Health·Sophie D WalshYael Delayahu
May 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Manuel J CuestaVictor Peralta
Feb 3, 2009·Human Molecular Genetics·George KirovMichael C O'Donovan
May 13, 2011·Schizophrenia Bulletin·Philip D HarveyLarry J Siever
Aug 29, 2012·Schizophrenia Bulletin·David R RoalfRaquel E Gur
May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Apr 22, 2015·NeuroImage·Christopher W N SavilleChristoph Klein
Apr 8, 2010·European Journal of Pharmacology·Richard M O'ConnorJohn F Cryan
Jun 11, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·L BurkeS Frangou
Dec 2, 2011·CNS Neuroscience & Therapeutics·B SoleE Vieta
Jun 28, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stephen Z LevineAbraham Reichenberg
Nov 15, 2012·Schizophrenia Research·David R RoalfRuben C Gur
Jan 17, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Hendrik KoffijbergErik Buskens
Nov 1, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Philip D Harvey
Nov 30, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Anat RotsteinAbraham Reichenberg

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