Premorbid sleep, appetite, energy, and cognitive circadian profile in patients with depressive disorders

European Psychiatry : the Journal of the Association of European Psychiatrists
G BersaniF Pacitti

Abstract

Alterations of biological rhythms are well recognized to play a crucial role in the origin and maintenance of depression, but little is known about the profile of circadian rhythms at a premorbid age in adult depressed patients. The present study was aimed at investigating the association, if any, of depressive disorders with biological and behavioural rhythm modifications both at the time of observation and at an earlier age than the clinical onset of depression. The hypothesis was that such modifications could be an early biological index of vulnerability to the illness. One hundred and seventy-eight patients affected by DSM-IV Major Depressive Disorder were examined/observed, compared to a group of 178 matched healthy subjects. All the included subjects were asked to fill in a retrospective questionnaire reporting time of awakening and falling asleep and time of subjective peaks of appetite, energy and cognitive function during "Adolescence" (12-15 years), "Youth" (16-20 years) and "Present condition" periods. An advance of awakening time by about 20 minutes during "Adolescence" was reported in the depressed subjects as compared to the controls. Awakening is also reported as significantly (P<0.001) advanced by about 36 minut...Continue Reading

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