Prenatal alcohol exposure delays the development of the cortical barrel field in neonatal rats

Experimental Brain Research
Cecilia P MargretRobert S Waters

Abstract

In-utero alcohol exposure produces sensorimotor developmental abnormalities that often persist into adulthood. The rodent cortical barrel field associated with the representation of the body surface was used as our model system to examine the effect of prenatal alcohol exposure (PAE) on early somatosensory cortical development. In this study, pregnant female rats were intragastrically gavaged daily with high doses of alcohol (6 gm/kg body weight) throughout the first 20 days of pregnancy. Blood alcohol levels were measured in the pregnant dams on gestational days 13 (G13) and G20. The ethanol treated group (EtOH) was compared to the normal control chowfed (CF) group, nutritionally matched pairfed (PF) group, and cross-foster (XF) group. Cortical barrel development was examined in pups across all treatment groups from G25, corresponding to postnatal day 2 (P2), to G32 corresponding to P9. The EtOH and control group pups were weighed, anesthetized, and perfused. Brains were removed and weighed with, and without cerebellum and olfactory bulbs, and neocortex was removed and weighed. Cortices were then flattened, sectioned tangentially, and stained with a metabolic marker, cytochrome oxidase (CO) to reveal the barrel field. Progress...Continue Reading

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Citations

Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hani El ShawaKelly J Huffman
Nov 4, 2015·Brain Sciences·Balapal S Basavarajappa
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Mar 18, 2021·Alcoholism, Clinical and Experimental Research·Ruixiang WangRoh-Yu Shen

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