Prenatal alcohol exposure results in hyperactivity of the hypothalamic-pituitary-adrenal axis of the offspring: modulation by fostering at birth and postnatal handling

Alcoholism, Clinical and Experimental Research
K M Ogilvie, C Rivier

Abstract

Exposure of fetal rats to alcohol results in permanent hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast, postnatal handling or fostering have been reported to restrain HPA activity. Because of the deleterious consequences of a hyperresponsive HPA axis, we thought that the possibility that postnatal manipulations might be able to reverse the influence of prenatal alcohol treatment deserved investigation. To test this hypothesis, we exposed rat dams to alcohol by inhalation during the second week of gestation. At birth, pups were either fostered or remained with their dam. For the first 3 weeks, litters were handled daily for 15 min or left undisturbed. At 22 days of age, male and female pups were decapitated under basal conditions, after 10 min of mild electro-footshock, or 10 min after footshock had been terminated. As expected, prenatal exposure to alcohol induced increased adrenocorticotropin (ACTH) secretion in response to footshock, and postnatal handling of control pups resulted in a suppression of corticosterone and ACTH release, although changes in this latter hormone did not reach statistical significance. Surprisingly, however, pups exposed to alcohol that were also fostered and handled after...Continue Reading

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Citations

Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·S BarronJ A Willford
May 12, 2001·Neurotoxicology and Teratology·K I Gabriel, J Weinberg
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Sep 15, 2004·Neuroscience Letters·Eunkyue ParkAusma Rabe
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Aug 19, 2014·Developmental Psychobiology·Charlis RainekiJoanne Weinberg
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Oct 25, 2008·Pediatric Research·Leonhard SchäfferErnst Beinder
Dec 27, 2016·Frontiers in Neuroscience·Argelia E Rojas-MayorquínDaniel Ortuño-Sahagún

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