Prenatal and childhood exposure to poly- and perfluoroalkyl substances (PFAS) and cognitive development in children at age 8 years

Environmental Research
Ann M VuongAimin Chen

Abstract

Toxicological studies indicate that poly- and perfluoroalkyl substances (PFAS) may be neurotoxic, but human studies have yet to provide compelling evidence for PFAS' impact on cognitive abilities. To test whether prenatal and childhood PFAS are associated with cognitive abilities at 8 years and whether sex modifies these associations. We included 221 mother-child pairs from the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort in Cincinnati, OH (USA). We quantified PFAS in maternal serum at 16 ± 3 weeks gestation and in child serum at 3 and 8 years. We used the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) at age 8 years, assessing Full Scale IQ (FSIQ), verbal comprehension, perceptual reasoning, working memory, and processing speed. We used multiple informant models to estimate covariate-adjusted differences in WISC-IV scores by repeated ln-transformed PFAS. Prenatal and childhood perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were not associated with WISC-IV measures. We observed an increase of 4.1-points (95% CI 0.3, 8.0) and 5.7-points (95% CI 1.2, 10.2) in working memory with 1-ln unit increase in prenatal perfluorooctanoate (PFOA) and perfluorononanoat...Continue Reading

Citations

Oct 11, 2020·International Journal of Environmental Research and Public Health·Albeliz Santiago-ColónJohn Howard
Feb 15, 2021·Chemosphere·Fuhar DixitMadjid Mohseni
Feb 6, 2021·Frontiers in Endocrinology·Francesca CoperchiniLuca Chiovato
Mar 22, 2021·Environmental Research·Geetika KallooJoseph M Braun
Apr 22, 2021·Journal of Hazardous Materials·Christian CarrizosaMaria-Jose Lopez-Espinosa
Jul 1, 2021·International Journal of Hygiene and Environmental Health·Laura SerranoCarmen Freire
Sep 12, 2019·Chemical Research in Toxicology·Ravi SonkarMahua Choudhury
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas
Aug 28, 2021·Journal of Hazardous Materials·Chen LiuKurt D Pennell
Sep 18, 2021·Environmental Science. Processes & Impacts·Yuexin Cao, Carla Ng

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