Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers

Environment International
Marc-Andre VernerGina Muckle

Abstract

Whereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology. To evaluate prenatal and postnatal exposures to PCB-153, a proxy of total PCB exposure, and their relation to inattention and activity in 5-year-old Inuits from the Cord Blood Monitoring Program. Prenatal exposure to PCBs was informed by cord plasma PCB-153 levels. We used a validated pharmacokinetic model to estimate monthly infants' levels across the first year of life. Inattention and activity were assessed by coding of video recordings of children undergoing fine motor testing. We used multivariable linear regression to evaluate the association between prenatal and postnatal PCB-153 levels and inattention (n=97) and activity (n=98) at 5years of age. Cord plasma PCB-153 was not associated with inattention and activity. Each interquartile range (IQR) increase in estimated infant PCB-153 levels at 2months was associated with a 1.02% increase in the duration of inattention (95% CI: 0.04, 2.00). Statistical adjustment for the duration of breastfeeding slightly increased regression coefficients for postnatal level...Continue Reading

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Citations

Aug 31, 2016·Environment International·Olivier BoucherJoseph L Jacobson
Mar 25, 2018·Endocrine Connections·Bilal B MughalBarbara A Demeneix
Aug 28, 2019·Environmental Science and Pollution Research International·Martyna Pajewska-SzmytBogusław Buszewski
Feb 9, 2020·International Journal of Molecular Sciences·Carolyn Klocke, Pamela J Lein
Dec 19, 2019·Chemistry : a European Journal·Eric S Marsan, Craig A Bayse
Jan 29, 2019·Environmental Science and Pollution Research International·Martyna Pajewska-SzmytRenata Gadzała-Kopciuch
Jan 8, 2021·Current Epidemiology Reports·Ann M VuongAimin Chen
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas

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