Prenatal and Early Postnatal Environmental Enrichment Reduce Acute Cell Death and Prevent Neurodevelopment and Memory Impairments in Rats Submitted to Neonatal Hypoxia Ischemia

Molecular Neurobiology
Luz Elena Durán-CarabaliCarlos Alexandre Netto

Abstract

Environmental enrichment (EE) is an experimental strategy to attenuate the negative effects of different neurological conditions including neonatal hypoxia ischemia encephalopathy (HIE). The aim of the present study was to investigate the influence of prenatal and early postnatal EE in animals submitted to neonatal HIE model at postnatal day (PND) 3. Wistar rats were housed in EE or standard conditions (SC) during pregnancy and lactation periods. Pups of both sexes were assigned to one of four experimental groups, considering the early environmental conditions and the injury: SC-Sham, SC-HIE, EE-sham, and EE-HIE. The offspring were euthanized at two different time points: 48 h after HIE for biochemical analyses or at PND 67 for histological analyses. Behavioral tests were performed at PND 7, 14, 21, and 60. Offspring from EE mothers had better performance in neurodevelopmental and spatial memory tests when compared to the SC groups. HIE animals showed a reduction of IGF-1 and VEGF in the parietal cortex, but no differences in BDNF and TrkB levels were found. EE-HIE animals showed reduction in cell death, lower astrocyte reactivity, and an increase in AKTp levels in the hippocampus and parietal cortex. In addition, the EE was al...Continue Reading

References

Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jun 18, 1997·Brain Research. Developmental Brain Research·J TowfighiS J Vannucci
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
May 9, 2003·Pediatric Research·Stephane V SizonenkoChris Williams
Sep 3, 2003·Nature Reviews. Genetics·Peter Carmeliet
Dec 23, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc-Marie JolyChristiane Charriaut-Marlangue
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura CanceddaLamberto Maffei
Oct 2, 2004·Neuropharmacology·Alessandro SaleLamberto Maffei
Feb 14, 2006·Current Alzheimer Research·Matthew J During, Lei Cao
Aug 23, 2006·Nature Reviews. Neuroscience·Jess Nithianantharajah, Anthony J Hannan
Aug 26, 2006·Neurobiology of Learning and Memory·Lenir Orlandi PereiraCarlos Alexandre Netto
Sep 29, 2006·Neurotoxicology and Teratology·Alexandre M FaveroCristina W Nogueira
Nov 1, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sylvain RenolleauChristiane Charriaut-Marlangue
Jan 12, 2008·The American Journal of Pathology·Masato KoikeYasuo Uchiyama
Feb 17, 2009·Pediatric Neurology·Jerome Y Yager, Stephen Ashwal
May 12, 2009·Behavioural Brain Research·Laurence Coutellier, Hanno Würbel
Dec 8, 2009·Behavioural Brain Research·Jessica E SparlingCatherine Bielajew
Dec 19, 2009·Cell Death and Differentiation·L BaroncelliL Maffei
Jul 24, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Laurent Kappeler, Michael J Meaney
Nov 6, 2010·Science·Marc R Freeman
Dec 24, 2010·Cell Communication and Signaling : CCS·Ganta Vijay ChaitanyaPhanithi Prakash Babu
Jan 18, 2011·Physiology & Behavior·Vanessa KazlauckasDiogo R Lara
Jan 29, 2011·Developmental Psychobiology·Phyllis E Mann, Kristen J Gervais
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joel V FaustinoZinaida S Vexler
Dec 17, 2011·Behavioural Brain Research·Richelle MychasiukRobbin Gibb
Jan 17, 2012·Brain Research·Eduardo Farias SanchesCarlos Alexandre Netto
Mar 21, 2012·Nature Reviews. Neuroscience·Ana M Fernandez, Ignacio Torres-Alemán
May 19, 2012·Behavioural Brain Research·Ateret Rosenfeld, Aron Weller
Jun 22, 2012·Neural Plasticity·José Fernando Maya-VetencourtLamberto Maffei
Feb 7, 2013·European Journal of Internal Medicine·P RoggeroF Mosca
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sara BaldiniNicoletta Berardi
Jul 31, 2013·Acta Pharmacologica Sinica·Fudong Liu, Louise D McCullough

❮ Previous
Next ❯

Citations

Jun 20, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A NettoS V Sizonenko
Nov 30, 2018·Frontiers in Behavioral Neuroscience·Debora CutuliLaura Petrosini
Dec 5, 2018·Frontiers in Neuroscience·Natalia N NalivaevaIgor A Zhuravin
Dec 20, 2018·Brain Plasticity·María Llorens-Martín
Aug 20, 2021·Frontiers in Pediatrics·Mark S Scher

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
electrophoresis

Software Mentioned

Image Studio Lite
ImageJ
NIH
ANY
SPSS
Maze

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.