Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis

Environmental Research
Dong-Wook LeeYun-Chul Hong

Abstract

Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional). We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis. We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood. To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health ...Continue Reading

Citations

Feb 26, 2020·International Journal of Molecular Sciences·Maria Elisabeth Street, Sergio Bernasconi
Dec 26, 2018·The Science of the Total Environment·Zhongming BuCong Dong
Nov 15, 2020·Journal of Hazardous Materials·Mihir Tanay DasLakhveer Singh
Mar 9, 2021·Biological Trace Element Research·Nurgül GünaydinAli Ertekin
Mar 20, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Roya PournejatiHamid Reza Karbalaei-Heidari
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas
Nov 19, 2021·Journal of Paediatrics and Child Health·Christos SymeonidesSarah Dunlop

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