Prenatal and postnatal lead exposure and early cognitive development: longitudinal study in Saudi Arabia

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
I al-SalehAbdullah Rabah

Abstract

The goal of this study was to assess the effect of prenatal and postnatal lead exposure on early cognitive development of infants using the Bayley Scale of Infant Development (BSID-I) at the age of 6, 12, 18, and 24 months in a longitudinal study. Based on the results of 653 cord blood lead levels, infants were classified into three groups for neuropsychological assessments: low lead risk (<10th percentile) and high lead risk (>10th percentile) of the distribution of cord blood lead level were designated as low (< or = 1.045 microg/dL) and high (> or = 3.466 microg/dL) lead risk groups. Blood lead levels in between the <10th and >90th percentile were designated as mid lead risk group. A total of 66 infants were supposed to be selected from each group for a follow-up study. Of these, only 106 participated 6 months after the study. During the follow-up study, the dropout was very high with attrition rates of 74.5%, 52.8%, and 39.6% during the 12, 18, and 24 months. Mean blood lead levels increased from 3.36 to 4.45 microg/dL between the ages of 6 and 24 months, but the standardized Mental Development Index (MDI) and Psychomotor Development Index (PDI) decreased from 99.26 and 98.13 (6 months old) to 93.29 and 82.52, respectively ...Continue Reading

Citations

Sep 13, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Rajendra Prasad ParajuliChiho Watanabe
Nov 26, 2010·International Journal of Hygiene and Environmental Health·Iman Al-SalehAbdullah Rabah
Jul 13, 2013·Environment International·Isabelle SioenGreet Schoeters
Feb 12, 2020·International Journal of Molecular Sciences·Karina ChibowskaIrena Baranowska-Bosiacka
Sep 16, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Kimberly A Allen
May 24, 2020·International Journal of Molecular Sciences·Luana Ketlen Reis LeãoRafael Rodrigues Lima

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