Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children

Environmental Research
Nozomi TatsutaHiroshi Satoh

Abstract

Low-level lead exposure during childhood is associated with deficit in child IQ. However, the association between prenatal lead exposure and child IQ remains inconsistent. The objective of our study was to examine the association between prenatal/postnatal lead exposure and child IQ at the age of 12. We obtained data pertaining to cord-blood and child-blood lead levels and IQ for 286 children from a prospective birth cohort study (Tohoku Study of Child Development). IQ was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition. Simultaneously, the Boston Naming Test (BNT) was used to assess the children's language ability. The median lead level in the cord blood was 0.8 μg/dL (5th-95th percentiles, 0.4-1.4 μg/dL), and that in the blood of 12-year-old children was 0.7 μg/dL (0.4-1.1 μg/dL). IQ and BNT scores were significantly lower in boys than in girls; therefore, multiple regression analysis was conducted separately for boys and girls. Among boys, IQ was associated with child-blood lead (B = -16.362, p = 0.033) but not cord-blood lead (B = -6.844, p = 0.309). When boys were divided into four groups according to the child-blood lead levels, there was a significant decreasing trend for IQ. The score with cue...Continue Reading

References

Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
Nov 1, 1990·Archives of Environmental Health·C B Ernhart, T Greene
Mar 1, 1987·International Journal of Epidemiology·S J PocockM A Smith
Apr 1, 1983·The Journal of Pediatrics·D C Bellinger, H L Needleman
Dec 11, 1997·Neurotoxicology and Teratology·P GrandjeanP J Jørgensen
Aug 3, 1999·American Journal of Epidemiology·P GrandjeanN Keiding
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Feb 23, 2005·Occupational and Environmental Medicine·M L BleeckerC G Vaughan
May 6, 2006·Environmental Health Perspectives·Lourdes SchnaasEstela Perroni
Aug 8, 2006·Neurotoxicology·Steven G Gilbert, Bernard Weiss
Sep 18, 2007·Neurotoxicology·Pamela J SurkanDavid C Bellinger
Feb 22, 2008·Environmental Health Perspectives·Todd A JuskoRichard L Canfield
May 30, 2008·PLoS Medicine·Kim M CecilBruce P Lanphear
Oct 23, 2008·Environmental Health Perspectives·Paul W StewartThomas Darvill
Apr 7, 2009·Neurotoxicology and Teratology·Meeyoung O MinSuchitra Nelson
Mar 17, 2010·Neurotoxicology·Christopher J BrubakerKim M Cecil
Apr 26, 2011·Environmental Health and Preventive Medicine·Jun YoshinagaMasayuki Kaji
May 4, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Teresa SławińskaRobert M Malina
Jun 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·U S KesmodelE L Mortensen
Jun 10, 2014·Environmental Health Perspectives·Subin ParkBung-Nyun Kim
Oct 9, 2014·Environmental Health and Preventive Medicine·Cimi IlmiawatiFujio Kayama
Jul 21, 2015·International Journal of Occupational Medicine and Environmental Health·Kinga PolańskaWojciech Hanke
Jul 21, 2015·JAMA Pediatrics·Nicole L HairSeth D Pollak
Nov 12, 2016·Psychiatrikē = Psychiatriki·Th VorvolakosM Samakouri
Oct 3, 2017·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Neda Alvarez-OrtegaJesus Olivero-Verbel
Dec 23, 2017·Scientific Reports·Huaiting GuRanran Song
Nov 6, 2018·International Journal of Environmental Research and Public Health·José A Menezes-FilhoDonna Mergler
Apr 20, 2019·Journal of Exposure Science & Environmental Epidemiology·Shoji F NakayamaUNKNOWN Japan Environment and Children’s Study Group

❮ Previous
Next ❯

Citations

Jan 6, 2021·Biomolecules·Marc MesnilDenis Sarrouilhe
Feb 23, 2021·Environmental Science and Pollution Research International·Ram B Jain
May 21, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Xue-Ning LiYing Liu
Jun 29, 2021·Journal of Chemical Neuroanatomy·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Giornale italiano di medicina del lavoro ed ergonomia
P CartaF Sanna Randaccio
Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
H QinX Zhao
International Journal of Behavioral Medicine
Kyung-Shin LeeYun-Chul Hong
© 2021 Meta ULC. All rights reserved