May 15, 2012

Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization

American Journal of Respiratory and Critical Care Medicine
Yueh-Hsiu Mathilda ChiuRosalind J Wright


Critical periods for programming early wheeze risk may include pregnancy and infancy. Effects of timing remain poorly understood. Associations among prenatal and postnatal maternal stress and children's wheeze were prospectively examined in 653 families. Effect modification by maternal sensitization was also examined. Stress was indexed by a maternal negative life events (NLEs) score (range, 0-9) ascertained during pregnancy and between 1 and 2 years postpartum. Mothers reported child wheeze every 3 months up to age 2 years. Relationships of prenatal and postnatal maternal NLEs with repeated wheeze (≥2 episodes) were examined using logistic regression adjusting for covariates. Penalized splines were implemented to explore possible nonlinear associations. We also examined the interaction between prenatal stress and maternal sensitization indexed by allergen-specific IgE from maternal prenatal serum. Adjusted models considering prenatal or postnatal NLEs alone both showed an exposure-response relationship between higher stress and child wheeze. When considering prenatal and postnatal stress concurrently, only children of mothers with high stress in both periods were significantly more likely to wheeze (adjusted odds ratio, 3.04; ...Continue Reading

  • References37
  • Citations42


  • References37
  • Citations42


Mentioned in this Paper

Mental Suffering
Odds Ratio
Allergen (brand of diphenylpyraline)
Prenatal brand of multivitamin
Fetal Stress
Analysis, Event History

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