Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

Gut Microbes
Shermel B ShermanJennifer W Hill

Abstract

Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We then completed a gut microbiota and cardiometabolic profile of the adult female offspring. The metabolic assessment revealed that adult PNA rats had increased body weight and increased mRNA expression of adipokines: adipocyte binding protein 2, adiponectin, and leptin in inguinal white adipose tissue. Radiotelemetry analysis reve...Continue Reading

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Citations

Mar 3, 2020·Nutrition Research Reviews·Ericka Moreno-MendezMaria-Luisa Lazo-de-la-Vega-Monroy
Aug 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Cong HanZhen-Qiang Qi
Aug 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Nesrin Damla EyupogluBulent Okan Yildiz
Jan 3, 2021·Journal of Endocrinological Investigation·Z LiangD Yang
Nov 3, 2020·Frontiers in Cellular and Infection Microbiology·Yumei ZhouZhuoxin Yang
Jun 3, 2021·Biomedicines·Chien-Ning Hsu, You-Lin Tain
Mar 26, 2021·Journal of Neurogastroenterology and Motility·Kichul Yoon, Nayoung Kim

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Methods Mentioned

BETA
ELISA
Assay
PCR
Phyloseq
dissection

Software Mentioned

QIIME
USEARCH
Image J
ANOSIM
PICRUSt
Greengenes
Phyloseq
GraphPad Prism

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