Prenatal Antidepressant Use and Risk of Adverse Neonatal Outcomes.

Pediatrics
Gretchen BandoliKristin Palmsten

Abstract

To estimate the risk of neonatal outcomes from patterns of prenatal antidepressant use. From the OptumLabs Data Warehouse, 226 932 singleton deliveries were identified. Antidepressant claims with coverage between the last menstrual period and 35 weeks' gestation were converted to fluoxetine equivalents, and a longitudinal cluster analysis was performed. Outcomes included major cardiac malformations (11.7 of 1000 births), preterm birth (75.7 of 1000 births), and newborn respiratory distress (54.2 of 1000 births). The lowest trajectory was the primary reference group, and depression and anxiety with no antidepressant claims served as secondary reference groups. From 15 041 (6.6%) pregnancies exposed to an antidepressant, use patterns were best described as (1) low use (∼10 mg/day) with first-trimester reduction, (2) low sustained use (∼20 mg/day), (3) moderate use (∼40 mg/day) with first-trimester reduction, (4) moderate sustained use (∼40 mg/day), and (5) high sustained use (∼75 mg/day). Moderate sustained use increased the risk of major cardiac malformations, although results included the null when compared with depression or anxiety reference groups. Moderate sustained (adjusted risk ratio [RR] 1.31; 95% confidence interval [C...Continue Reading

References

Nov 7, 2002·Archives of Pediatrics & Adolescent Medicine·Adriana Moldovan CosteiGideon Koren
Jun 6, 2007·American Journal of Obstetrics and Gynecology·William O CooperWayne A Ray
Jun 29, 2007·The New England Journal of Medicine·Carol LouikAllen A Mitchell
Aug 31, 2007·Pharmacoepidemiology and Drug Safety·Robert L DavisUNKNOWN HMO Research Network Center for Education, Research in Therapeutics
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Susan E AndradeRichard Platt
May 3, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Tim F OberlanderClyde Hertzman
Jan 6, 2009·The American Journal of Psychiatry·Sengwee TohSonia Hernández-Díaz
Jun 29, 2011·Computer Methods and Programs in Biomedicine·Christophe Genolini, Bruno Falissard
Mar 24, 2012·American Journal of Epidemiology·Kristin PalmstenSonia Hernández-Díaz
May 3, 2012·Pharmacoepidemiology and Drug Safety·Andrea V MargulisSonia Hernández-Díaz
Feb 5, 2013·General Hospital Psychiatry·Krista F HuybrechtsSonia Hernández-Díaz
Jul 23, 2013·Epidemiology·Kristin PalmstenSonia Hernández-Díaz
Nov 12, 2013·Best Practice & Research. Clinical Obstetrics & Gynaecology·Shona Ray, Zachary N Stowe
Apr 18, 2014·Pharmacoepidemiology and Drug Safety·Kristin PalmstenSonia Hernández-Díaz
Jun 19, 2014·The New England Journal of Medicine·Krista F HuybrechtsSonia Hernández-Díaz
Jul 10, 2014·Health Affairs·Paul J WallaceWilliam H Crown
Apr 26, 2015·Journal of Affective Disorders·Yu HayasakaToshi A Furukawa
Oct 19, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·A C EkeV Berghella
Oct 25, 2016·Journal of Affective Disorders·Emily E CameronLianne M Tomfohr-Madsen
Mar 25, 2017·Pharmacoepidemiology and Drug Safety·Caroline Hurault-DelarueChristine Damase-Michel
Jan 18, 2018·Archives of Women's Mental Health·Gretchen BandoliKristin Palmsten
Mar 1, 2018·Pharmacoepidemiology and Drug Safety·Kristin PalmstenChristina D Chambers

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Citations

Jan 17, 2021·The Journal of Pediatrics·Kendall A UlbrichKatherine L Wisner
Apr 9, 2021·Expert Review of Neurotherapeutics·Bhuvaneshwari SethuramanKrishnamachari Srinivasan
Jun 9, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Xuerong WenKimford J Meador
Jun 9, 2021·Epidemiologic Reviews·Mollie E WoodMarleen M H J van Gelder

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